Latest Update: 2014-04-07 13:16:21

生物化學暨生物物理實驗室Biochemistry and Biophysics Lab.

研究領域 | Research Background

Biochemical and biophysical studies on misfolding of prion proteins.

Nanoimaging of prion fibrils.

Prion diseases are progressive neurodegenerative disorders that affect both humans and animals, such as Creutzfeldt-Jakob disease (CJD) in humans, bovine spongiform encephalopathy (mad cow disease) in cows and Scrapie in sheep. Up to date, there is no therapeutic treatment to control or to cure prion diseases. Prion diseases are caused by accumulation of prion amyloid fibrils resulted from misfolding of normal α-helix rich prion proteins into β-sheet rich prion proteins. How prion monomers misfold and convert to fibrils is not know yet. We are interested in studying the mechanism of the prion fibril formation by molecular spectroscopy and nanoimaging.

實驗室成員

博士生

謝易軒

碩士生

林紀汾、李依儒、游昆樺、陳泰元

專題生

丁韋丞、盧昱融、鄭承平(化生系:林怡君、莊英聖、何思慧、王笙容)

已畢業學生

碩士:(99級)林聖傑、曾彥達,(100級)高華德、王星淳、游藝璟、張水靈

專題生:徐銘鑫、林聖傑、何永洪、賴奎宏、吳博仁、范錦財、簡維邦、楊紫君、張水靈、游昆樺、林玉梅、林邦齊