聯絡資訊 | Contact

Address	168, University Road, Min-Hsiung, Chia-Yi Taiwan, R. O. C.
    Tel	(05)2720411 ext. Office 66508  Lab 61520
    Fax	(05)2722871 
  Email	biockt@ccu.edu.tw

學歷 | Education

2002   美國南加州大學醫學院病理生物學 Ph.D.

經歷 | Employment

2015/8-present 國立中正大學生物醫學科學系 教授

2017/7 -2018/8 國立中正大學生物醫學科學系 系主任

2015/7 -2017/8 國立中正大學生命科學系 系主任

2010/7 -2015/8 國立中正大學生命科學系 副教授

2005/7 -2010/8 國立中正大學生命科學系暨分子生物研究所 助理教授

2002 -2005       美國加州大學洛杉磯分校(UCLA)醫學系 博士後研究員

研究專長 | Professions

癌症基因治療、癌症研究

研究領域 | Research Background

1. 基因治療

2. 癌症基因與抗藥性研究

3. 發展高效率基因傳輸病毒載體

榮譽獎項 | Honor

1. 獲科技部108年度(第57屆)補助科學與技術人員國外短期研究

2. 2017年教育部邁向頂尖大學計畫特殊優秀研究人才獎勵

3. The Susan G. Komen Breast Cancer Foundation postdoctoral research award (2005)

4. USC Keck School of Medicine research assistantship (1999-2002)

5. California Breast Cancer Research Program pre-doctoral fellowship award (1999-2000)

6. The Susan G. Komen Breast Cancer Foundationdissertation research award (1999)

論文與著作 | Publication

  1. Chou JL, Su HY, Chen LY, Liao YP, Hartman-Frey C, Lai YH, Yang HW, Deatherage DE, Kuo CT, Huang YW, Yan PS, Hsiao SH, Tai CK, Lin HJL, Davuluri RV, Chao TK, Nephew KP, Huang THM, Lai HC, and Chan MWY. Promoter hypermethylation of FBXO32, a novel TGF-β/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer. Laboratory Investigation. March 2010; 90(3): 414-425. (SCI)
  2. Lu YC, Luo YP, Wang YW, and Tai CK*. Highly efficient gene transfer to solid tumors in vivo by tumor-selective replicating retrovirus vectors. International Journal of Molecular Medicine. May 2010; 25(5): 769-775. (SCI) (*Correspondence)
  3. Ho CL, Huang YC, Tai CK, Liu ST, Wang JK, Wang WM, and Huang SM. Modulation of the Zac1's transactivation and coactivation functions via PML and Daxx within distinct subcellular localizations. The International Journal of Biochemistry & Cell Biology. June 2010; 42(6): 902-910. (SCI)
  4. Tai CK*, Wang WJ, Lai YH, Logg CR, Parker WB, Li YF, Hong JS, Sorscher EJ, Chen TC, and Kasahara N. Enhanced efficiency of prodrug activation therapy by tumor-selective replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene. Cancer Gene Therapy. September 2010; 17(9): 614-623. (SCI) (*Correspondence)
  5. Lu YC, Chen YJ, Yu YR, Lai YH, Cheng JC, Li YF, Shen CH, and Tai CK*. Replicating retroviral vectors for oncolytic virotherapy of experimental hepatocellular carcinoma. Oncology Reports. July 2012; 28(1): 21-26. (SCI) (*Correspondence)
  6. Lin MS, Tai CK*, Shen CH, Ma TL, and Tu DG. Primary erector spinae pyomyositis with an epidural abscess. The Spine Journal. September 2013; 13(9): 1156-1157. (SCI) (*co-first author)
  7. Li YF, Lin CC, and Tai CK*. Interaction of Intercellular Adhesion Molecule 1 (ICAM1) Polymorphisms and Environmental Tobacco Smoke on Childhood Asthma. Int. J. Environ. Res. Public Health. June 2014; 11(6): 6504-6516. (SCI) (*Correspondence)
  8. Tu DG, Tai CK*. 99mTc DMSA Scan Predicts Dilating Vesicoureteral Reflux in Young Children With a First Febrile Urinary Tract Infection a Population-Based Cohort Study: A Suggestion Regarding the Statistical Analysis Method Used. Clin. Nucl. Med. October 2014; 39(10): 938. (SCI) (*Correspondence)
  9. Lai YH, He RY, Chou JL, Chan M, Li YF, Tai CK*. Promoter hypermethylation and silencing of tissue factor pathway inhibitor-2 in oral squamous cell carcinoma. Journal of Translational Medicine. September 2014; 12(1): 237, 1-13. (SCI) (*Correspondence)
  10. Lai YH, Lin CC, Chen SH, Tai CK*. Tumor-specific suicide gene therapy for hepatocellular carcinoma by transcriptionally targeted retroviral replicating vectors. Gene Therapy. February 2015; 22(2): 155-162. (SCI) (*Correspondence)
  11. Lin HY, Hung SK, Lee MS, Chiou WY, Huang TT, Tseng CE, Shih LY, Lin RI, Lin JM, Lai YH, Chang CB, Hsu FC, Chen LC, Tsai SJ, Su YC, Li SC, Lai HC, Hsu WL, Liu DW, Tai CK, Wu SF, Chan MW. DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study. Oncotarget. January 20, 2015; 6(2): 915-934. (SCI)
  12. Chou JL, Huang RL, Shay J, Chen LY, Lin SJ, Yan PS, Chao WT, Lai YH, Lai YL, Chao TK, Lee CI, Tai CK, Wu SF, Nephew KP, Huang THM, Lai HC, Chan MW. Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients. Clinical Epigenetics. January 2015; 7(1):1, 1-11. (SCI)
  13. Li YF, Hsiao YH, Lai YH, Chen YC, Chen YJ, Chou JL, Chan M, Lin YH, Tsou YA, Tsai MH, Tai CK*. DNA methylation profiles and biomarkers of oral squamous cell carcinoma. Epigenetics. March 2015; 10(3): 229-236. (SCI) (*Correspondence)
  14. Chen YJ, Chen SY, Lovel R, Ku YC, Lai YH, Hung CL, Li YF, Lu YC, Tai CK*. Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncology Letters. September 2016; 12(3): 2107-2114. (SCI) (*Correspondence)
  15. Tu DG, Chang WW, Jan MS, Tu CW, Lu YC, Tai CK*. Promotion of metastasis of thyroid cancer cells via NRP-2-mediated induction. Oncology Letters. Nov 2016; 12(5): 4224-4230. (SCI) (*Correspondence)
  16. Chao CN, Yang YH, Wu MS, Chou MC, Fang CY, Lin MC, Tai CK, Shen CH, Chen PL, Chang D, Wang M. Gene therapy for human glioblastoma using neurotropic JC virus-like particles as a gene delivery vector. Scientific Reports. Feb 2018; 8(1): 2213. (SCI)

Conference papers

  1. Lai YH, Lin CC, and Tai CK. Transcriptional targeting of tumor-selective retrovirus to hepatocellular carcinoma. (Abstract selected for poster presentation at the 18th Symposium on Recent Advances in Cellular and Molecular Biology, Ping-Tung, Taiwan, January 20-22, 2010.)
  2. Chou JL, Su HY, Chen LY, Liao YP, Hartman-Frey C, Lai YH, Yang HW, Deatherage DE, Kuo CT, Huang YW, Yan PS, Hsiao SH, Tai CK, Lin HJL, Davuluri RV, Chao TK, Nephew KP, Huang THM, Lai HC, and Chan MWY. Promoter hypermethylation of FBXO32, a novel TGF-β/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer. (Abstract selected for poster presentation at the 101st Annual Meeting of the American Association for Cancer Research, Washington, DC, April 17-21, 2010.)
  3. Lu YC, Lovel R, Hung CL, and Tai CK. Effects of RNAi on drug resistance in oral squamous cell carcinoma. (Abstract selected for poster presentation at the 15th Taiwan Joint Cancer Conference, Taipei, Taiwan, May 1-2, 2010.)
  4. Lai YH and Tai CK. Tumor-Selective Suicide Gene Therapy by Transcriptionally Targeted Replicating Retrovirus Vectors. Molecular Therapy supplement. May, 2011; 19: S201. (Abstract selected for poster presentation at the 14th Annual Meeting of the American Society of Gene & Cell Therapy, Seattle, Washington, May 18-21, 2011.)
  5. Lu YC, Lai YH, Chen SH, and Tai CK. Targeting of Tumor-Selective Retrovirus Vectors to Cancer. (Abstract selected for poster presentation at the 16th Taiwan Joint Cancer Conference, Taipei, Taiwan, April 30-May 1, 2011.)
  6. Li YF, Hsiao YH, and Tai CK. Methylation Array Analysis of Tissue DNA in Oral Squamous Cell Cancer Patients in Taiwan. J Cancer Sci Ther Special Issues: Proceedings of Cancer Science & Therapy-2011. S1.19-20. (Abstract selected for oral presentation at the International Conference on Cancer Science & Therapy, Las Vegas, Nevada, August 15-17, 2011.)
  7. He RY, Chen YJ, Lai YH, and Tai CK. Epigenetic Status and Role of Bone Morphogenetic Protein 3 (BMP3) in Oral Squamous Cell Carcinoma. (Abstract selected for poster presentation at the 27th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 17-18, 2012.)
  8. Chiu YT, Chang HF, Lin SC, Yang YH, and Tai CK. Adipose-derived Stem Cells as the Vehicles of Therapeutic Retrovirus for Treating Glioma. (Abstract selected for poster presentation at the 27th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 17-18, 2012.)
  9. Lai YH and Tai CK. Tumor-Selective Suicide Gene Therapy for Hepatocelluar Carcinoma by Transcriptionally Targeted Replicating Retrovirus Vectors. (Abstract selected for oral presentation at the 27th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 17-18, 2012.)
  10. Chen YJ, Chen SY, Lovel R, and Tai CK. Enhancing the Chemosensitivity of Oral Cancer by Downregulation of EGFR and MRP2 Genes via Lentivirus Vector-Mediated RNAi. (Abstract selected for poster presentation at the 27th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 17-18, 2012.)
  11. Lai YH and Tai CK. Tumor-specific suicide gene therapy for hepatocelluar carcinoma by transcriptionally targeted replicating retrovirus vectors. (Abstract selected for poster presentation at 2012 International Society for Cell & Gene Therapy of Cancer meeting, Singapore, October 4-6, 2012.)
  12. Tai CK. Tumor-selective replicating retroviral vectors for gene therapy of cancer. (Invited talk at the 2nd International Congress on Natural Sciences, Kaohsiung, Taiwan, October 23-25, 2012)
  13. Chen YC and Tai CK. DNA Methylation Level and Gene Expression of FLT4 in Oral Cancers. (Abstract selected for poster presentation at the 29th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 15-16, 2014.)
  14. Liu WR, Li YF, and Tai CK. Genome-wide Methylation Analysis of Tissue DNA in Oral Squamous Cell Cancer Patients. (Abstract selected for poster presentation at the 13th International Conference on Pathology, San Diego, CA, June 26-27, 2017.)
  15. Chen YJ, Lai YL, Chan M, and Tai CK. The role of HOXA5 in oral squamous cell carcinoma. (Abstract selected for poster presentation at The 76th Annual Meeting of Japanese Cancer Association, Yokohama, Japan, September 28-30, 2017.)
  16. Kan CH, Chen YC, Chen YJ, Tai CK and Chang D. Correlation between Methylation Status of MGMT and Therapeutic effect of Temozolomide in Gliomas. (Abstract selected for poster presentation at The 76th Annual Meeting of Japanese Cancer Association, Yokohama, Japan, September 28-30, 2017.)