聯絡資訊 | Contact

Address	168, University Road, Min-Hsiung, Chia-Yi Taiwan, R. O. C.
    Tel	(05)2720411 ext. Office 66508  Lab 61520
    Fax	(05)2722871 
  Email	

學歷 | Education

2002 Ph.D. 美國南加州大學醫學院病理生物學 (Pathobiology)

1993 B.S. 國立台灣大學農藝學系

經歷 | Employment

2015/8-present 國立中正大學生命科學系 教授

2010/8-2015/7 國立中正大學生命科學系 副教授

2005/8-2010/7 國立中正大學生命科學系暨分子生物研究所 助理教授

2002 -2005 美國加州大學洛杉磯分校(UCLA)醫學系 博士後研究員

研究專長 | Professions

基因治療、癌症研究

研究領域 | Research Background

1. 癌症基因治療與免疫治療

2. 癌症研究

3. RNAi對癌細胞抗藥基因表現之影響

4. 發展高效率基因傳輸病毒載體

榮譽獎項 | Honor

1. California Breast Cancer Research Program pre-doctoral fellowship award (1999-2000)

2. The Susan G. Komen Breast Cancer Foundation dissertation research award (1999)

3. USC Keck School of Medicine research assistantship (1999-2002)

4. The Susan G. Komen Breast Cancer Foundation postdoctoral research award (2005)

論文與著作 | Publication

  1. Chou JL, Su HY, Chen LY, Liao YP, Hartman-Frey C, Lai YH, Yang HW, Deatherage DE, Kuo CT, Huang YW, Yan PS, Hsiao SH, Tai CK, Lin HJL, Davuluri RV, Chao TK, Nephew KP, Huang THM, Lai HC, and Chan MWY. Promoter hypermethylation of FBXO32, a novel TGF-β/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer. Laboratory Investigation.March 2010; 90(3): 414-425. (SCI)
  2. Lu YC, Luo YP, Wang YW, and Tai CK*. Highly efficient gene transfer to solid tumors in vivo by tumor-selective replicating retrovirus vectors. International Journal of Molecular Medicine. May 2010; 25(5): 769-775. (SCI) (*Correspondence)
  3. Ho CL, Huang YC, Tai CK, Liu ST, Wang JK, Wang WM, and Huang SM. Modulation of the Zac1's transactivation and coactivationfunctions via PML and Daxx within distinct subcellular localizations. The International Journal of Biochemistry & Cell Biology. June 2010; 42(6): 902-910. (SCI)
  4. Tai CK*, Wang WJ, Lai YH, Logg CR, Parker WB, Li YF, Hong JS, Sorscher EJ, Chen TC, and Kasahara N. Enhanced efficiency of prodrug activation therapy by tumor-selective replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene. Cancer Gene Therapy. September 2010; 17(9): 614-623. (SCI) (*Correspondence)
  5. Lu YC, Chen YJ, Yu YR, Lai YH, Cheng JC, Li YF, Shen CH, and Tai CK*. Replicating retroviral vectors for oncolytic virotherapy of experimental hepatocellular carcinoma. Oncology Reports. July 2012; 28(1): 21-26. (SCI) (*Correspondence)
  6. Lin MS, Tai CK*, Shen CH, Ma TL, and Tu DG. Primary erector spinae pyomyositis with an epidural abscess. The Spine Journal. September 2013; 13(9): 1156-1157. (SCI) (*co-first author)
  7. Li YF, Lin CC, and Tai CK*. Interaction of Intercellular Adhesion Molecule 1 (ICAM1) Polymorphisms and Environmental Tobacco Smoke on Childhood Asthma. Int. J. Environ. Res. Public Health. June 2014; 11(6): 6504-6516. (SCI) (*Correspondence)
  8. Tu DG, Tai CK*. 99mTc DMSA Scan Predicts Dilating Vesicoureteral Reflux in Young Children With a First Febrile Urinary Tract Infection a Population-Based Cohort Study: A Suggestion Regarding the Statistical Analysis Method Used. Clin. Nucl. Med. October 2014; 39(10): 938. (SCI) (*Correspondence)
  9. Lai YH, He RY, Chou JL, Chan M, Li YF, Tai CK*. Promoter hypermethylation and silencing of tissue factor pathway inhibitor-2 in oral squamous cell carcinoma. Journal of Translational Medicine. September 2014; 12(1): 237, 1-13. (SCI) (*Correspondence)
  10. Lai YH, Lin CC, Chen SH, Tai CK*. Tumor-specific suicide gene therapy for hepatocellular carcinoma by transcriptionally targeted retroviral replicating vectors. Gene Therapy. February 2015; 22(2): 155-162. (SCI) (*Correspondence)
  11. Lin HY, Hung SK, Lee MS, Chiou WY, Huang TT, Tseng CE, Shih LY, Lin RI, Lin JM, Lai YH, Chang CB, Hsu FC, Chen LC, Tsai SJ, Su YC, Li SC, Lai HC, Hsu WL, Liu DW, Tai CK, Wu SF, Chan MW. DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study. Oncotarget. January 20, 2015; 6(2): 915-934. (SCI)
  12. Chou JL, Huang RL, Shay J, Chen LY, Lin SJ, Yan PS, Chao WT, Lai YH, Lai YL, Chao TK, Lee CI, Tai CK, Wu SF, Nephew KP, Huang THM, Lai HC, Chan MW. Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients. Clinical Epigenetics. January 2015; 7(1):1, 1-11. (SCI)
  13. Chen YJ, Chen SY, Lovel R, Ku YC, Lai YH, Hung CL, Li YF, Lu YC, Tai CK*. Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncology Letters (2015, in press). (SCI) (*Correspondence)
  14. Li YF, Hsiao YH, Lai YH, Chen YC, Chen YJ, Chou JL, Chan M, Lin YH, Tsou YA, Tsai MH, Tai CK*. DNA methylation profiles and biomarkers of oral squamous cell carcinoma. Epigenetics. March 2015; 10(3): 229-236. (SCI) (*Correspondence)
  15. Tu DG, Jan MS, Hsu CD, Chen YC, Lee YR, Tai CK*. Promotion of metastasis of thyroid cancer cells via NRP-2-mediated induction. Oncology Letters (in press). (SCI) (*Correspondence)

Conference papers

  1. Tai C.K., Shichinohe, T., Nishida, M., Hegerich-Gilliam, S., Bochner, B.H., and Kasahara, N. Development of lentiviral vectors for anti-angiogenic gene therapy. Cancer Gene Therapy supplement, 7(12): S15. (Abstract selected for poster presentation at Gene Therapy of Cancer 9th International Conference, San Diego, California, December 7-9, 2000.)
  2. Tai C.K., Shichinohe, T., Nishida, M., Hegerich-Gilliam, S., Bochner, B.H., and Kasahara, N. Comparative utility of lentivirus and adenovirus vectors for anti-angiogenic gene therapy. (Selected for oral presentation at Gene Therapy of Cancer 9th International Conference, San Diego, California, December 7-9, 2000.)
  3. Logg, C.R., Logg, A., Tai C.K., Park, J., Press, M.F., Bochner, B.H., Anderson, W.F., Cannon, P.M., and Kasahara, N. Targeting gene delivery to cancer cells using replication-competent retrovirus vectors. (Abstract selected for oral presentation at the 3rd Cold Spring Harbor Biotechnology Symposium on Vector Targeting Strategies for Therapeutic Gene Delivery, Cold Spring Harbor, New York, March 15-18, 2001. )
  4. Shichinohe, T., Tai C.K., Nishida, M., Hegerich-Gilliam, S., Naldini, L., Bochner, B.H., and Kasahara, N. Lentivirus vector-mediated gene delivery of endostatin results in suppression of tumor growth in vivo. (Abstract selected for oral presentation at the 4th Annual Meeting of the American Society of Gene Therapy, Seattle, Washington, May 29-June 3, 2001.)
  5. Shichinohe, T., Logg, C. R., Soifer, H., Tai C.K., Logg, A., Cannon, P.M., Anderson, W.F., and Kasahara, N. Development of novel vectors for anti-angiogenic gene therapy of cancer. (Abstract selected for oral presentation at the 7th Annual Meeting of the Japan Society of Gene Therapy, Tokyo, Japan, July 5-7, 2001.)
  6. Wang, W.J., Tai C.K., Kasahara, N., and Chen, T.C. Use of replication competent retroviral vectors in malignant gliomas. (Abstract selected for poster presentation at the 6th Annual Meeting of the Society for Neuro-Oncology, Washington DC, November 15-18, 2001.)
  7. Shichinohe, T., Tai C.K., Mizutani, K., Sazawa, A., Kirihara, M., Bochner, B.H., and Kasahara, N. Antiangiogenic suppression of tumor growth in vivo by adenoviral and lentiviral gene transfer of thrombospondin-1 and endostatin. (Abstract selected for oral presentation at the 10th International Conference on Gene Therapy of Cancer, San Diego, California, December 13-16, 2001.)
  8. Logg, C.R., Logg, A., Tai C.K., Wang, W.J., Anderson, W.F., Cannon, P.M., Bochner, B.H., Chen, T.C., and Kasahara, N. Replication-competent retrovirus vectors targeted to cancer cells achieve highly efficient gene transfer to solid tumors in vivo. (Abstract selected for oral presentation at the 10th International Conference on Gene Therapy of Cancer, San Diego, California, December 13-16, 2001.)
  9. Logg, C. R., Tai C.K., Logg, A., Yoon, L.T.K., Lee, A.S., Anderson, W.F., Bochner, B.H., Cannon, P.M., and Kasahara, N. Cell-specific transcriptional regulation and long-term genomic stability of replication-competent retrovirus vectors engineered for efficient transmission of exogenous genes. (Abstract selected for oral presentation at the 2002 Cold Spring Harbor Symposium on Retroviruses, Cold Spring Harbor, New York, May 22-24, 2002.)
  10. Tai C.K., Wang, W.J., Logg, C.R., Shichinohe, T., Chen, T.C., and Kasahara, N. Replication-competent retroviral vectors for highly efficient and tumor-selective suicide gene therapy. Molecular Therapy supplement. May, 2002; 5(5): S180. (Abstract presented at the 5th Annual Meeting of the American Society of Gene Therapy, Boston, Massachusetts, June 5-9, 2002.)
  11. Wang, W.J., Tai C.K., Kasahara, N., and Chen, T.C. Use of replication competent retroviral vectors (RCR) in malignant gliomas. Molecular Therapy supplement. May, 2002; 5(5): S287. (Abstract presented at the 5th Annual Meeting of the American Society of Gene Therapy, Boston, Massachusetts, June 5-9, 2002.)
  12. Shichinohe, T., Sazawa, A., Kim, J.H., Tai C.K., Mizutani, K., Bochner, B.H., and Kasahara, N. Lentivirus-vector mediated antiangiogenicgene therapy with thrombospondin-1 and endostatin result in suppression of tumor growth in vivo. (Abstract presented at the 5th Annual Meeting of the American Society of Gene Therapy, Boston, Massachusetts, June 5-9, 2002.)
  13. Yoon, T.K.L., Logg, C.R., Shichinohe, T., Tai C.K., Lee, A.S., and Kasahara, N. Use of Grp78 Promoter for tumor-selective stress-inducible regulation of virus vector transgene expression and regulation. Molecular Therapy supplement. May, 2002; 5(5): S203. (Abstract presented at the 5th Annual Meeting of the American Society of Gene Therapy, Boston, Massachusetts, June 5-9, 2002.)
  14. Logg, C.R., Logg, A., Tai C.K., Wang, W.J., Chen, T.C., Bochner, B.H., and Kasahara, N. Highly efficient gene transfer to solid tumors in vivo by targeted replication-competent retrovirus vectors. (Abstract presented at the 8th Annual Meeting of the Japan Society of Gene Therapy, Tokyo, Japan, July 18-20, 2002.)
  15. Tai C.K., Sazawa, A., Logg, C.R., Lee, R., Park, J., Press, M., Anderson, W.F., Cannon, P., and Kasahara, N. Improving retroviral vectors for gene therapy of breast cancer. (Abstract presented at the Department of Defense Breast Cancer Research Program Era of Hope Meeting, Orlando, Florida, September 25-28, 2002.)
  16. Tai C.K., Wang, W.J., Sazawa, A., Kim, J.H., Logg, C.R., Park, J., Press, M., Anderson, W.F., Cannon, P.M., Stripecke, R., Faure, E.,Margalit, R., Bochner, B.H., Chen, T. and Kasahara, N. Therapeutic efficacy of highly efficient and tumor-restricted gene transfer in vivo by replication-competent retroviral vectors. (Abstract presented at the 10th annual meeting of the European Society of Gene Therapy, Antibes Juan-les Pins, France, October 12-16, 2002.)
  17. Chen, T.C., Wang, W.J., Tai C.K., and Kasahara, N. Use of replication competent retroviruses containing the suicide gene cytosine deaminase in the treatment of malignant gliomas. (Abstract presented at the annual meeting of the American Academy of Neurological Surgeons, Scottsdale, Arizona, October 2002.)
  18. Tai C.K., Wang, W.J., Logg, C.R., Chen, T.C., and Kasahara, N. Highly efficient cell killing in vitro and in vivo by replication-competent retroviral vectors expressing cytosine deaminase and purine nucleoside phosphorylase. (Abstract selected for oral presentation at the 11th International Conference on Gene Therapy of Cancer, San Diego, California, December 12-14, 2002.)
  19. Tai C.K., Wang, W.J., Chen, T.C., Sazawa, A., Faure, E., Logg, C.R., Bochner, B.H., Yoon, L.T.K., Lee, A.S., Cannon, P.M., Anderson, W.F. and Kasahara, N. Development of replication-competent retrovirus vectors for cancer gene therapy: in vivo therapeutic efficacy, tumor-selectivity, and safety. (Abstract selected for oral presentation at the 11th International Conference on Gene Therapy of Cancer, San Diego, California, December 12-14, 2002.)
  20. Tai C.K., Wang, W.J., Logg, C.R., Sazawa, A., Faure, E., Anderson, W.F., Chen, T.C., and Kasahara, N. Replication-competent retrovirus vector-mediated cancer gene therapy: highly efficient and tumor-specific transfer of suicide genes in vivo resulting in tumor eradication and long-term survival. Molecular Therapy supplement. May, 2003; 7(5): S314-315. (Abstract selected for oral presentation at the 6th Annual Meeting of the American Society of Gene Therapy, Washington D.C., June 4-8, 2003.)
  21. Tai C.K., Wang, W.J., Sazawa, A., Logg, C.R., Logg, A., Ohori, M., Kikuchi, E., Bochner, B.H., Chen, T., and Kasahara, N. Tumor-selectively replicating retrovirus vectors achieve highly efficient intratumoral therapeutic gene transfer and long term survival benefit in vivo. (Abstract selected for oral presentation at the 9th Annual Meeting of the Japan Society of Gene Therapy, Tokyo, Japan, July 19-21, 2003.)
  22. Tai C.K., Wang, W.J., Chen, T.C., Logg, C.R., Bochner, B.H., Solly, S.K., Frisen, C., Klatzmann, D., and Kasahara, N. Replication-Competent Retrovirus Vectors for Cancer Gene Therapy: Persistence as the key to long-term survival. (Abstract selected for oral presentation at 2003 International Society of Cancer Gene Therapy meeting, Alexandria, Egypt, October 22-24, 2003.)
  23. Tai C.K., Wang, W.J., Logg, C.R., Chen, T., and Kasahara, N. Replication-competent retrovirus vectors for oncolytic therapy of gliomas: highly efficient suicide gene transfer and stable expression results in long-term survival benefit in vivo. Neuro-Oncology, 5(4): 308. (Abstract selected for oral presentation at the 8th Annual Meeting of the Society for Neuro-Oncology, Keystone, Colorado, November 13-16, 2003.)
  24. Wang, W.J., Tai C.K., Kasahara, N., Chen, T.C. The use of replication-competent retroviral vectors in an immunocompetent animal glioma model. Neuro-Oncology, 5(4): 309. (Abstract selected for poster presentation at the 8th Annual Meeting of the Society for Neuro-Oncology, Keystone, Colorado, November 13-16, 2003.)
  25. Tai C.K., Wang WJ, Solly S, Frisen C, Logg C, Klatzmann D, Chen TC, and Kasahara N. Essential role of genomic integration and anti-viral immune response for the in vivo therapeutic efficacy and safety of cancer gene therapy with tumor-selective replication-competent retrovirus vectors. (Abstract selected for oral presentation at the 12th International Conference on Gene Therapy of Cancer, San Diego, California, December 11-13, 2003.)
  26. Wang W, Tai C.K., Kershaw AD, Solly SK, Klatzmann D, Kasahara N, and Chen TC. Replication competent retrovirus vector mediated gene therapy for malignant gliomas. (Abstract selected for oral presentation at the 12th International Conference on Gene Therapy of Cancer, San Diego, California, December 11-13, 2003.)
  27. Tai C.K., Wang W, Logg CR, Solly SK, Frisen C, Eiden MV Klatzmann D, Chen TC, and Kasahara N. Replication-competent retrovirus vectors for cancer gene therapy: in vivo therapeutic efficacy and safety. Cancer Gene Therapy. December, 2004; 11(12): 853. (Abstract selected for oral and poster presentation at 2004 International Society of Cancer Gene Therapy meeting, Singapore, February 20-22, 2004. Selected as best presentation award.)
  28. Hiraoka K, Tai C.K., Logg CR, Katoh H, and Kasahara N. High efficiency suicide gene therapy for colon cancer using replication-competent retrovirus vectors. Cancer Gene Therapy. December, 2004; 11(12): 852. (Abstract selected for poster presentation at 2004 International Society of Cancer Gene Therapy meeting, Singapore, February 20-22, 2004.)
  29. Wang W, Tai C.K., Kershaw AD, Solly SK, Klatzmann D, Kasahara N and Chen TC. RCR vectors mediated gene therapy for malignantgliomas. Neuro-Oncology. October 2004; 6(4): 341-341. (Abstract selected for poster presentation at the 9th Annual Meeting of the Society for Neuro-Oncology, Toronto, Canada, November 18-21, 2004.)
  30. Gupta V, Wang WJ, Tai C.K., Bading JR, Kasahara N, Chen TC. Molecular imaging of tumors by pet using a replication competent retrovirus in monitoring gene therapy. Neuro-Oncology. October 2004; 6(4): 366. (Abstract selected for poster presentation at the 9th Annual Meeting of the Society for Neuro-Oncology, Toronto, Canada, November 18-21, 2004.)
  31. Tai C.K., Wang WJ, Logg CR, Parker WB, Hong JS, Li YF, Sorscher EJ, Chen TC, and Kasahara N. Gene therapy for malignant gliomas by high efficiency retrovirus vector expressing Escherichia coli purine nucleoside phosphorylase. (Abstract selected for poster presentation at the 96th Annual Meeting of the American Association for Cancer Research, Anaheim, California, April 16-20, 2005.)
  32. Cheng JC, Yu YR, and Tai C.K. Suicide gene transfer with replicating retroviral vectors enhances tumor cell death after administration of prodrug. (Abstract selected for poster presentation at 2008 Symposium on Cellular Systems Biology, Chia-Yi, Taiwan, March 5, 2008.)
  33. Lin CC, Lai YH, and Tai C.K. Tumor-Specific Targeting of Murine Leukemia Virus-Based Replication-Competent Retroviral Vector.(Abstract selected for poster presentation at 2008 Symposium on Cellular Systems Biology, Chia-Yi, Taiwan, March 5, 2008.)
  34. Lai YH, Lin CC, and Tai C.K. Transcriptional targeting of tumor-selective retrovirus to hepatocellular carcinoma. (Abstract selected for poster presentation at the 18th Symposium on Recent Advances in Cellular and Molecular Biology, Ping-Tung, Taiwan, January 20-22, 2010.)
  35. Chou JL, Su HY, Chen LY, Liao YP, Hartman-Frey C, Lai YH, Yang HW, Deatherage DE, Kuo CT, Huang YW, Yan PS, Hsiao SH, Tai C.K., Lin HJL, Davuluri RV, Chao TK, Nephew KP, Huang THM, Lai HC, and Chan MWY. Promoter hypermethylation of FBXO32, a novel TGF-β/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer. (Abstract selected for poster presentation at the 101st Annual Meeting of the American Association for Cancer Research, Washington, DC, April 17-21, 2010.)
  36. Lu YC, Lovel R, Hung CL, Tai C.K. Effects of RNAi on drug resistance in oral squamous cell carcinoma. (Abstract selected for poster presentation at the 15th Taiwan Joint Cancer Conference, Taipei, Taiwan, May 1-2, 2010.)