李政怡 Cheng-I Lee

168, University Road, Min-Hsiung Chia-Yi Taiwan, R. O. C.
Tel: (05) 2720411 ext. 66511(Office) , 61523(Lab)
Fax: (05) 2722871
Email: biocil@ccu.edu.tw

• 學歷

  Ph.D. 1993-2001 Intercollege Genetic program, The Pennsylvania State University, University Park, PA, USA.
  B.S. 1984-1988 Department of Biology, TungHai University, Taichung, Taiwan.

• 經歷

  1992 - 1996年 學士 清華大學化學系
  1996 - 1998年 碩士 清華大學化學系
  1998 - 1999年 研究助理 中央研究院化學所
  1999 - 2005年 博士 美國耶魯大學化學系
  2005 - 2007年 博士後研究員 美國馬禮蘭大學生物技術研究所

• Education and Experience

  B. S., Chemistry, National Tsing Hua University, Taiwan 1992 - 1996
  M. S., Chemistry, National Tsing Hua University, Taiwan 1996 - 1998
  Ph. D., Biophysical Chemistry, Yale University, USA 1999 - 2005
  Post-Doctoral Associate Medical Biotechnology Center,
  　University of Maryland Biotechnology Institute, USA 2005 – 2007

• 研究興趣與專長

  Biochemical and biophysical studies on misfolding of prion proteins.

  Nanoimaging of prion fibrils.

  Prion diseases are progressive neurodegenerative disorders that affect both humans and animals, such as Creutzfeldt-Jakob disease (CJD) in humans, bovine spongiform encephalopathy (mad cow disease) in cows and Scrapie in sheep. Up to date, there is no therapeutic treatment to control or to cure prion diseases. Prion diseases are caused by accumulation of prion amyloid fibrils resulted from misfolding of normal α-helix rich prion proteins into β-sheet rich prion proteins. How prion monomers misfold and convert to fibrils is not know yet. We are interested in studying the mechanism of the prion fibril formation by molecular spectroscopy and nanoimaging.

• Honors

  Distinguish National Science Council (Taiwan) undergraduate research award 1996

• Presentations

  • Cheng-I Lee and Gary W. Brudvig. “Investigation of the Functional Role of Ca2+ in the Oxygen-Evolving Complex of Photosystem II.” Keystone Symposium: Membrane Proteins, Taos, NM, 2003, Poster presentation.
  • Cheng-I Lee, John S. Vrettos and Gary W. Brudvig. “Investigation of the Effect of Monovalent Cations on the Oxygen Evolving Activity in Photosystem II.” East Regional Photosynthesis Conference, Woods Hole, MA, 2002, Poster presentation.
  • Sergei Vassiliev, Cheng-I Lee, Gary W. Brudvig and Doug Bruce. “Structure-Based Kinetic Modeling of Excited-State Transfer and Trapping in Histidine-Tagged Photosystem II Core Complexes from Synechocystis.” Eastern Regional Photosynthesis Conference, Woods Hole, MA, 2002, Poster presentation.
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• 論文與著作

  • Li-Shiun Chen, Cheng-I Lee, Yuan-Pern Lee, “Isomers of SO2: Infrared absorption of SOO in solid argon”, Journal of Chemical Physics, (1996) 105, 9454-9460 [SCI].
  • Cheng-I Lee, Yuan-Pern Lee, Xuefeng Wang, Qi-Zong Qin, “Isomers of N2O3: Observation of trans-cis N2O3 in solid Ar”, Journal of Chemical Physics (1998) 109, 10446-10455 [SCI].
  • Sergei Vassiliev, Cheng-I Lee, Gary W. Brudvig, Doug Bruce, “Structure-based kinetic modeling of excited-state transfer and trapping in histidine-tagged Photosystem II core complexes from Synechocystis”, Biochemistry (2002) 41, 12236-12243 [SCI].
  • Cheng-I Lee, Gary W. Brudvig, “Investigation of the functional role of Ca2+ in the oxygen-evolving complex of Photosystem II: a pH-dependence study of the substitution of Ca2+ by Sr2+”, Journal of the Chinese Chemical Society (2004) 51, 1221-1228 [SCI].
  • Leonid Breydo, Ying Sun, Natallia Makarava, Cheng-I Lee, Vera Novitskaia, Olga Bocharova, Joseph P. Y. Kao, Ilia, V. Baskakov, “Nonpolar substitution at the C-terminus of the prion protein, a mimic of the glycosylphosphatidulinositol anchor, partially impairs amyloid fibril formation”, Biochemistry (2007) 46, 852-61 [SCI].
  • Cheng-I Lee, K. V. Lakshmi, Gary W. Brudvig, “Probing the functional role of Ca2+ in the oxygen-evolving complex of Photosystem II by metal ion inhibition”, Biochemistry (2007) 46, 3211-3223 [SCI].
  • Cheng-I Lee, Qingyuan Yang, Veronique Perrier, Ilia V. Baskakov, “The dominant negative effect of the Q218K variant of the prion protein does not require protein X”, Protein Science (2007) 16, 2166-2173 [SCI].
  • Natallia Makarava, Cheng-I Lee, Valeriy G. Ostapchenko, Ilia V. Baskakov, “Highly promiscuous nature of prion polymerization”, Journal of Biological Chemistry (2007) 282, 36704-36713 [SCI].
  • Ying Sun, Natallia Makarava, Cheng-I Lee, Pongpan Laksanalamai, Frank T. Robb, Ilia V. Baskakov, “Conformational stability of PrP amyloid fibrils controls their smallest possible fragment size.” Journal of Molecular Biology. (2008) 376, 1155-1167 [SCI].