李政怡

CHENG-I, LEE 

Contact information 聯絡資訊

 Tel: (05)2720411 ext. Office 66511 Lab 61523

 Fax: (05)2722871

 Email: biocil@ccu.edu.tw

Education and Experience學經歷

1992 - 1996年            學士                   清華大學化學系

1996 - 1998年            碩士                   清華大學化學系 

1998 - 1999年            研究助理            中央研究院化學所

1999 - 2005年            博士                   美國耶魯大學化學系

2005 - 2007年            博士後研究員     美國馬里蘭大學生物技術研究所

2007 – 2013年           助理教授            國立中正大學生命科學系

2013 – 2017 年          副教授                國立中正大學生命科學系

2017 – 2019 年          副教授                國立中正大學生物醫學科學系

2019 迄今                  教授                   國立中正大學生物醫學科學系

2021 – 2024年           教授兼系主任      國立中正大學生物醫學科學系

Expertise 專長
  • 生物物理化學
  • 蛋白質工程與模擬
  • 生物醫學之光化學
Honor 榮譽

Teaching award at National Chung Cheng University  國立中正大學教學優良獎

Young scholar award at National Chung Cheng University  國立中正大學青年學者獎

Publication 論文與著作
  1. Li-Shiun Chen, Cheng-I Lee, Yuan-Pern Lee, “Isomers of SO2: Infrared absorption of SOO in solid argon”, Journal of Chemical Physics, (1996) 105, 9454-9460 [SCI].
  2. Cheng-I Lee, Yuan-Pern Lee, Xuefeng Wang, Qi-Zong Qin, “Isomers of N2O3: Observation of trans-cis N2O3 in solid Ar”, Journal of Chemical Physics (1998) 109, 10446-10455 [SCI].
  3. Sergei Vassiliev, Cheng-I Lee, Gary W. Brudvig, Doug Bruce, “Structure-based kinetic modeling of excited-state transfer and trapping in histidine-tagged Photosystem II core complexes from Synechocystis”, Biochemistry (2002) 41, 12236-12243 [SCI].
  4. Cheng-I Lee, Gary W. Brudvig, “Investigation of the functional role of Ca2+ in the oxygen-evolving complex of Photosystem II: a pH-dependence study of the substitution of Ca2+ by Sr2+”, Journal of the Chinese Chemical Society (2004) 51, 1221-1228 [SCI].
  5. Leonid Breydo, Ying Sun, Natallia Makarava, Cheng-I Lee, Vera Novitskaia, Olga Bocharova, Joseph P. Y. Kao, Ilia, V. Baskakov, “Nonpolar substitution at the C-terminus of the prion protein, a mimic of the glycosylphosphatidulinositol anchor, partially impairs amyloid fibril formation”, Biochemistry (2007) 46, 852-61 [SCI].
  6. Cheng-I Lee, K. V. Lakshmi, Gary W. Brudvig, “Probing the functional role of Ca2+ in the oxygen-evolving complex of Photosystem II by metal ion inhibition”, Biochemistry (2007) 46, 3211-3223 [SCI].
  7. Cheng-I Lee, Qingyuan Yang, Veronique Perrier, Ilia V. Baskakov, “The dominant negative effect of the Q218K variant of the prion protein does not require protein X”, Protein Science (2007) 16, 2166-2173 [SCI].
  8. Natallia Makarava, Cheng-I Lee, Valeriy G. Ostapchenko, Ilia V. Baskakov, “Highly promiscuous nature of prion polymerization”, Journal of Biological Chemistry (2007) 282, 36704-36713 [SCI].
  9. Ying Sun, Natallia Makarava, Cheng-I Lee, Pongpan Laksanalamai, Frank T. Robb, Ilia V. Baskakov, “Conformational stability of PrP amyloid fibrils controls their smallest possible fragment size.” Journal of Molecular Biology. (2008) 376, 1155-1167 [SCI].
  10. 江素玉、李政怡、馮學深、蔡宛霖、羅祥文, “同步輻射圓二色光譜實驗站與應用”科儀新知 (2009), 30(5), 9-17.
  11. Cheng-I Lee*, Nai-yuan Chang, “Characterizing the denatured state of human prion 121–230.” Biophysical Chemistry (2010) 151, 86-90 [SCI].
  12. Barbara Yang, Kuen-Hua You, Shing-Chuen Wang, Hau-Ren Chen and Cheng-I Lee, “The Effects of Trimethylamine N-Oxide on the Structural Stability of Prion Protein.” Neurodegenerative Diseases, (2011) p311-326.
  13. Jian-Chau Luo, Shing-Chuen Wang, Wei-Bang Jian, Chien-Hsing Chen, Jaw-Luen Tang and Cheng-I Lee*, “Formation of amyloid fibrils from b-amylase.” FEBS Letters, (2012) 586, 680-685 [SCI].
  14. Jaw-Luen Tang, Po-Jen Wu, Shing-Chuen Wang and Cheng-I Lee*, “Insights into structural properties of denatured human prion 121-230 at melting temperature studied by replica exchange molecular dynamics.” Journal of Physical Chemistry-B, (2012) 116, 3305–3312 [SCI].
  15. Li-Chen Yang, Yen-Shang Lai, Chin-Ming Tsai, Yi-Ting Kong, Cheng-I Lee,* and Cheng-Liang Huang*, “One-pot synthesis of monodispersed silver nanodecahedra with optimal SERS activities using seedless photo-assisted citrate reduction method.” Journal of Physical Chemistry-C, (2012) 116, 24292-24300 [SCI].
  16. Wen-Tsai Ji, Cheng-I Lee, Jeff Yi-Fu Chen, Ya-Ping Cheng, Sheng-Ru Yang, Jung-Hua Chen1, Hau-Ren Chen*, “Areca Nut Extract Induces Pyknotic Necrosis in Serum-Starved Oral Cells via Increasing Reactive Oxygen Species and Inhibiting GSK3b: An Implication for Cytopathic Effects in Betel Quid Chewers.” PLOS One, (2013) 8, e63295 [SCI].
  17. Ruchira Chatterjee, Christopher S. Coates, Sergey Milikisiyants, Cheng-I Lee, Arlene Wagner, Oleg G. Poluektov and K. V. Lakshmi*, “High-Frequency Electron Nuclear Double-Resonance Spectroscopy Studies of the Mechanism of Proton-Coupled Electron Transfer at the Tyrosine-D Residue of Photosystem II.” Biochemistry, (2013) 52, 4781-4790 [SCI].
  18. Chi-Fen Lin, Kun-Hua Yu, Cheng-Ping Jheng, Raymond Chung* and Cheng-I Lee*, “Curcumin Reduces Amyloid Fibrillation of Prion Protein and Decreases Reactive Oxidative Stress.” Pathogens, (2013) 2, 506-519 [SCI].
  19. Shen-Jie Lin, Kun-Hua Yu, Jhih-Ru Wu, Chin-Fa Lee, Cheng-Ping Jheng, Hau-Ren Chen and Cheng-I Lee*, “Liberation of GPI-Anchored Prion from Phospholipids Accelerates Amyloidogenic Conversion” International Journal of Molecular Science, (2013) 14, 17943-17957 [SCI].
  20. Morris M. H. Hsu, Pei-Yu Huang, Yao-Chang Lee, Yuang-Chuen Fang, Michael W.Y. Chan, and Cheng-I Lee*, “FT-IR microspectrometry reveals the variation of membrane polarizability due to epigenomic effect on epithelial ovarian cancer” International Journal of Molecular Science, (2014) 15, 17963-17973 [SCI].
  21. Jian-Liang Chou, Lin-Yu Chen, Sheng-Jie Lin, Pearlly S. Yan, Wei-Ting Chao, Cheng-I Lee, Kenneth P. Nephew, Tim H.-M. Huang, Hung-Cheng Lai* and Michael W.Y. Chan*, “Hypermethylation of a TGF-b target, ABCA1 is associated with poor prognosis in ovarian cancer patients” Clinical Epigenetics, (2015) 7, 1-11 [SCI].
  22. Yi-Ci Li, Yu-Ting Kuo, Po-Yuan Huang, Sidney S. Yang, Cheng-I Lee*, and Tai-Huei Wei*, “Thermal Lensing Effect of CS2 Studied with Femtosecond Laser Pulses” submitted to Physical Chemistry Chemical Physics (2015) 17, 24738-24747 [SCI].
  23. Li-Shu Lee, Yu-Ting Kuo, Chi-Chen Wang, Yi-Ci Li, Po-Yuan Huang, Cheng-I. Lee* and Tai-Huei Wei*, “Mechanism of short-pulse-induced solute migration in comparison to continuous-light-driven thermal diffusion” RSC Advances (2016) 6, 20671-20680 [SCI].
  24. Nai-yuan Chang, Yi-Ci Li, Cheng-Ping Jheng, Yu-Ting Kuo and Cheng-I Lee*, “Characterizing the denatured state ensemble of ubiquitin under native conditions using replica exchange molecular dynamics” RSC Advances (2016) 6, 95584-95589 [SCI].
  25. Yi-Ci Li, Yu-Ting Kuo, Po-Yuan Huang, Cheng-I Lee and Tai-Huei Wei*, “Ultrashort-laser-pulse-induced thermal lensing in pure H2O and a NaCl-H2O solution” RSC Advances (2016) 6, 112727-112737 [SCI].
  26. Yi-Hsuan Hsieh, Jun-Hui Zhang, Wen-Ching Chuang, Kun-Hua Yu, Xian-Bin Huang, Yao-Chang Lee and Cheng-I Lee*, “Effect of Combined Treatment with Photodynamic and Chemical Therapies on Candida albicans” International Journal of Molecular Science (2018) 19, 337 [SCI].
  27. Wen-Hsuan Tsai, Kun-Hua Yu, Yi-Cheng Huang, and Cheng-I Lee*, "EGFR-targeted photodynamic therapy by curcumin-encapsulated chitosan/TPP nanoparticles" International Journal of Nanomedicine, (2018) 13, 903-916 [SCI].
  28. Yi-Hsuan Hsieh, Wen-Ching Chuang, Kun-Hua Yu, Cheng-Ping Jheng and Cheng-I Lee*, “Sequential photodynamic therapy with phthalocyanine encapsulated chitosan-tripolyphosphate nanoparticles and flucytosine treatment against Candida tropicalis” Pharmaceutics (2019) 11, 16 [SCI].
  29. Huan-I Jen, Zih-You Lin, Jin-Xun Guo and Cheng-I Lee*, “The effects of divalent cation-chelated prion fibrils on the immune response of EOC 13.31 microglia cells” Cells (2020) 9, 2285 [SCI].
  30. Kun-Hua Yu and Cheng-I Lee*, “Quercetin disaggregates prion fibrils and decreases fibril-induced cytotoxicity and oxidative stress” Pharmaceutics (2020) 12, 1081 [SCI].
  31. Kun-Hua Yu, Mei-Yu Huang, Yi-Ru Lee, Yu-Kie Lin, Hau-Ren Chen and Cheng-I Lee*, “The effect of octapeptide repeats on prion folding and misfolding” International Journal of Molecular Science (2021) 22, 1800 [SCI].
  32. Cheng-I Lee, Chu-Bin Liao, Chih-Shang Chen, Fen-Ying Cheng, Yu-Hsuan Chung, Yu-Chuan Wang, Sian-Yi Ciou, Wen-Yun Hsueh, Tzu-Hao Lo, Guan-Ru Huan, Hsin-Yi Huang, Chia-Shen Tsai, Yu-Jung Lu, Shih-Hsien Chuang, Jiann-Jyh Huang*, “Design and synthesis of 4-anilinoquinazolines as Raf kinase inhibitors. Part 1. Selective B-Raf/B-RafV600E and potent EGFR/VEGFR2 inhibitory 4-(3-hydroxyanilino)-6-(1H-1,2,3-triazol-4-yl)quinazolines” Bioorganic Chemistry (2021) 109, 104715 [SCI].
  33. Kun-Hua Yu, Cheng-Ping Jheng and Cheng-I Lee*, “Quercetin binding accelerates prion fibrillation into proteinase sensitive and loosely structured amyloids” Biomedicine & Pharmacotherapy (2022) 151, 113177 [SCI].
  34. Kun-Hua Yu, Cheng-Ping Jheng and Cheng-I Lee*, “Quercetin binding accelerates prion fibrillation into proteinase sensitive and loosely structured amyloids” Biomedicine & Pharmacotherapy (2022) 151, 113177 [SCI]. (doi: 10.1016/j.biopha.2022.113177)
  35. Dhivyabharathi Balakrishnan and Cheng-I Lee*, “Surface functionalization of bamboo with silver-reduced graphene oxide nanosheets to improve hydrophobicity and mold resistance” Coatings (2022) 12, 980 [SCI].
  36. Cheng-Ping Jheng and Cheng-I Lee*, “Combination of structure-based virtual screening, molecular docking and molecular dynamics approaches for the discovery of anti-prion fibril flavonoids” Frontiers in Molecular Bioscience (2023) 9, 1088733 [SCI]. (doi: 10.3389/fmolb.2022.1088733).