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Chien-Kuo Tai



Contact information

 Tel: (05)2720411 ext. Office 66508 Lab 61520

 Fax: (05)2722871

 Email: biockt@ccu.edu.tw

Academic qualication

University of Southern California, Ph.D., 2002, Pathobiology

Professional Experience
  • Postdoctoral Researcher, Department of Medicine, UCLA, CA, 2002-2005
  • Assistant Professor, Department of Life Science, National Chung Cheng University, Taiwan, 2005- 2010
  • Associate Professor, Department of Life Science, National Chung Cheng University, Taiwan, 2010- 2015
  • Professor & Department Chair, Department of Life Science, National Chung Cheng University, Taiwan, 2015-2018

Cancer Gene Therapy、Cancer Research

  • 基因治療
  • 癌症基因與抗藥性研究
  • 發展高效率基因傳輸病毒載體
  • The Susan G. Komen Breast Cancer Foundation dissertation research award (1999)
  • California Breast Cancer Research Program pre-doctoral fellowship award (1999-2000)
  • USC Keck School of Medicine research assistantship (1999-2002)
  • The Susan G. Komen Breast Cancer Foundation postdoctoral research award (2005)
  • 2017年教育部邁向頂尖大學計畫特殊優秀研究人才獎勵
  • 獲科技部108年度(第57屆)補助科學與技術人員國外短期研究
  1. Lu YC, Luo YP, Wang YW, and Tai CK*.  Highly efficient gene transfer to solid tumors in vivo by tumor-selective replicating retrovirus vectors. International Journal of Molecular Medicine. May 2010; 25(5): 769-775. (SCI) (*Correspondence)
  2. Ho CL, Huang YC, Tai CK, Liu ST, Wang JK, Wang WM, and Huang SM.  Modulation of the Zac1's transactivation and coactivation functions via PML and Daxx within distinct subcellular localizations.  The International Journal of Biochemistry & Cell Biology. June 2010; 42(6): 902-910. (SCI)
  3. Tai CK*, Wang WJ, Lai YH, Logg CR, Parker WB, Li YF, Hong JS, Sorscher EJ, Chen TC, and Kasahara N.  Enhanced efficiency of prodrug activation therapy by tumor-selective replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene.  Cancer Gene Therapy. September 2010; 17(9): 614-623. (SCI) (*Correspondence)
  4. Lu YC, Chen YJ, Yu YR, Lai YH, Cheng JC, Li YF, Shen CH, and Tai CK*.  Replicating retroviral vectors for oncolytic virotherapy of experimental hepatocellular carcinoma.  Oncology Reports. July 2012; 28(1): 21-26. (SCI) (*Correspondence)
  5. Lin MS, Tai CK*, Shen CH, Ma TL, and Tu DG. Primary erector spinae pyomyositis with an epidural abscess. The Spine Journal. September 2013; 13(9): 1156-1157. (SCI) (*co-first author)
  6. Li YF, Lin CC, and Tai CK*.  Interaction of Intercellular Adhesion Molecule 1 (ICAM1) Polymorphisms and Environmental Tobacco Smoke on Childhood Asthma. Int. J. Environ. Res. Public Health. June 2014; 11(6): 6504-6516. (SCI) (*Correspondence)
  7. Tu DG, Tai CK*.  99mTc DMSA Scan Predicts Dilating Vesicoureteral Reflux in Young Children With a First Febrile Urinary Tract Infection a Population-Based Cohort Study: A Suggestion Regarding the Statistical Analysis Method Used. Clin. Nucl. Med. October 2014; 39(10): 938. (SCI) (*Correspondence)
  8. Lai YH, He RY, Chou JL, Chan M, Li YF, Tai CK*.  Promoter hypermethylation and silencing of tissue factor pathway inhibitor-2 in oral squamous cell carcinoma. Journal of Translational Medicine. September 2014; 12(1): 237, 1-13. (SCI) (*Correspondence)
  9. Lai YH, Lin CC, Chen SH, Tai CK*.  Tumor-specific suicide gene therapy for hepatocellular carcinoma by transcriptionally targeted retroviral replicating vectors. Gene Therapy. February 2015; 22(2): 155-162. (SCI) (*Correspondence)
  10. Chou JL, Huang RL, Shay J, Chen LY, Lin SJ, Yan PS, Chao WT, Lai YH, Lai YL, Chao TK, Lee CI, Tai CK, Wu SF, Nephew KP, Huang THM, Lai HC, Chan MW. Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients. Clinical Epigenetics. January 2015; 7(1):1, 1-11. (SCI)
  11. Li YF, Hsiao YH, Lai YH, Chen YC, Chen YJ, Chou JL, Chan M, Lin YH, Tsou YA, Tsai MH, Tai CK*.  DNA methylation profiles and biomarkers of oral squamous cell carcinoma. Epigenetics. March 2015; 10(3): 229-236. (SCI) (*Correspondence)
  12. Chen YJ, Chen SY, Lovel R, Ku YC, Lai YH, Hung CL, Li YF, Lu YC, Tai CK*.  Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncology Letters. September 2016; 12(3): 2107-2114. (SCI) (*Correspondence)
  13. Tu DG, Chang WW, Jan MS, Tu CW, Lu YC, Tai CK*.  Promotion of metastasis of thyroid cancer cells via NRP-2-mediated induction. Oncology Letters. Nov 2016; 12(5): 4224-4230. (SCI) (*Correspondence)
  14. Chao CN, Yang YH, Wu MS, Chou MC, Fang CY, Lin MC, Tai CK, Shen CH, Chen PL, Chang D, Wang M.  Gene therapy for human glioblastoma using neurotropic JC virus-like particles as a gene delivery vector. Scientific Reports. Feb 2018; 8(1): 2213. (SCI)
  15. Chen SH, Sun JM, Chen BM, Lin SC, Chang HF, Collins S, Chang D, Wu SF, Lu YC, Wang W, Chen TC, Kasahara N, Wang HE, Tai CK*. Efficient prodrug activator gene therapy by retroviral replicating vectors prolongs survival in an immune-competent intracerebral glioma model. Int. J. Mol. Sci. Feb 2020; 21(4): 1433. (SCI) (*Correspondence)
  16. Wu MT, Yeh WT, Wang YC, Chen PM, Liu CY, Tai CK, Tang FY, Li JR, Liu CC, Chiang EPI. MTHFR Knockdown Assists Cell Defense against Folate Depletion Induced Chromosome Segregation and Uracil Misincorporation in the DNA. Int. J. Mol. Sci. Aug 2021; 22(17): 9392. (SCI)
  17. Kuo YC, Yen MH, De S, Rajesh R, Tai CK.  Optimized lipopolymers with curcumin to enhance AZD5582 and GDC0152 activity and downregulate inhibitors of apoptosis proteins in glioblastoma multiforme. Biomaterials Advances. Nov 2023; 154: 213639. (SCI)
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