B.S., National Taiwan University, Agricultural Chemistry, 1985
M.S., National Taiwan University, Institute of Agricultural Chemistry, 1987
Ph.D., National Yang-Ming University, Institute of Microbiology and Immunology, 1998
Working Experience 經歷
2012.8-present Associate Professor, Department of Life Science, National Chung Cheng University
2002.2- 2012.7 Assistant Professor, Department of Life Science, National Chung Cheng University. Replication, infection and pathogenesis mechanisms of positive-strand RNA viruses.
2000.11-2002.1 Postdoctoral Fellow, with Dr. Paul Ahliquist, Institute for Molecular Virology, University of Wisconsin at Madison Purification of the RNA-dependent RNA polymerase complex of Flock House Virus (FHV) from yeast mitochondria.
1998.9-2000.10 Postdoctoral Fellow, with Dr. Soo-Chen Cheng (鄭淑珍), Institute of Molecular Biology, Academia Sinica. Characterization of protein factors in the Prp19p-associated complex.
1991.9-1998.8 Ph.D. Student, with Dr. Soo-Chen Cheng (鄭淑珍), Institute of Microbiology and Immunology, National Yang-Ming University. Establishment of genetic system to identify novel mRNA splicing factors in yeast.
1989.7-1991.8 Research Assistant, with Dr. Soo-Chen Cheng (鄭淑珍), Institute of Molecular Biology, Academia Sinica. Studies on mRNA splicing factors in yeast using biochemical approaches.
1987.7-1989.6 2nd Lieutenant, Military Service in Army.
1985.9-1987.6 Graduate Student, with Dr. Hsien-Yi Sung (宋賢一) and Jong-Ching Su (蘇仲卿), Laboratory of Biochemistry, Institute of Agricultural Chemistry, National Taiwan University. Research on carbohydrates metabolism in rice.
1984.9-1985.8 Undergraduate Student, with Dr. Hsien-Yi Sung (宋賢一) and Jong-Ching Su (蘇仲卿), Laboratory of Biochemistry, Department of Agricultural Chemistry, National Taiwan University. Research on enzyme purification in plants.
1998 Award of outstanding merit and high scholastic achievement in medical and pharmaceutical research sponsored by Wang Ming-Ning Memorial Foundation (王民寧優秀論文競賽獎)
1998 Award of excellent Ph. D. thesis sponsored by Dr. Chien-Tien Hsu (徐千田優秀論文競賽獎).
Lee, Y.-R., Wu, W.-C., Ji, W.-T., Chen, J.Y.-F., Cheng, Y.-P., Chiang, M.-K., and Chen, H.-R. (2012) Reversine suppresses oral squamous cell carcinoma via cell cycle arrest and concomitantly apoptosis and autophagy. Journal of Biomedical Science 19:9
Nimje, V. R., Chen, C.-Y., Chen, H.-R., Chen, C.-C., Huang, Y.-M., Tseng, M.-J., Cheng, K.-C., & Chang, Y.-F. (2012) Comparative bioelectricity production from various wastewaters in microbial fuel cells using mixed cultures and a pure strain of Shewanella oneidensis. Bioresour. Technol. 104:315-323.
Nimje, V.-R., Chen, C.-Y., Chen, C.-C., Tsaib, J.-Y., Chen, H.-R., Huangd, Y.-M., Jean, J.-S., Chang, Y.-F. and Shih, R.-C. Microbial fuel cell of Enterobacter cloacae: Effect of anodic pH microenvironment on current,power density, internal resistance and electrochemical losses. International Journal of Hydrogen Energy 36 (17):11093-11101.
Nimje, V. R., Chen, C.-Y., Chen, C.-C., Chen, H.-R., Tseng, M.-J., Jean, J.-S. & Chang, Y.-F. (2011) Glycerol degradation in single-chamber microbial fuel cells. Bioresour. Technol. Feb; 102, 2629-2634.
Jyoti Maity, Lin, T.-J., Cheng, P.-H., Chen, C.-Y., Reddy, A.-S., Atla, S.-B., Chang, Y.-F., Chen, H.-R., Chen, C.-C. Synthesis of brushite particles in reverse microemulsion of biosurfactant, surfactin. International Journal of Molecular Sciences 12(6):3821-3830.
Chen, H.-R., Chen, C.-C., Reddy, A. S., Chen, C.-Y., Li, W. R., Tseng, M.-J., Liu, H.-T., Pan, W., Maity, J.P. & Atla, S.B. (2011) Removal of mercury by foam fractionation using surfactin, a biosurfactant. Int. J. Mol. Sci. 12:8245-8258.
Huang, T.-T., Chen, J. Y.-F., Tseng, C.-E., Su, Y.-C., Ho, H.-C., Lee, M.-S., Chang, C.-T., Wong, Y.-K. and Chen, H.-R. (2010) Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan. J Formos Med Assoc 109,326-337.
Tseng, M.-Y., Liu, S.-Y., Chen, H.-R., Wu, Y.-J., Chiu, C.-C., Chan, P.-T., Chiang, W.-F., Liu, Y.-C., Lu, C.-Y., Jou, Y.-S. and Chen, J. Y.-F. (2009) Serine protease inhibitor (SERPIN) B1 promotes oral cancer cell motility and is over-expressed in invasive oral squamous cell carcinoma. Oral Oncol 45, 771-776.
Chen, J. Y.-F., Hung, C.-C., Huang, K.-L., Chen, Y.-T., Liu, S.-Y., Chiang, W.-F., Chen, H.-R., Yen, C.-Y., Wu, Y.-J., Ko, J.-Y. and Jou, Y.-S. (2008) Src family kinases mediate betel quid-induced oral cancer cell motility and could be a biomarker for early invasion in oral squamous cell carcinoma. Neoplasia 10, 1393-1401.
Liu, S.-Y., Chen, Y.-T., Tseng, M.-Y., Hung, C.-C., Chiang, W.-F., Chen, H.-R., Shieh, T.-Y., Chen, C.-H., Jou, Y.-S. and Chen, J.Y.-F. (2008) Involvement of microtubule-associated protein 2 (MAP2) in oral cancer cell motility: A novel biological function of MAP2 in non-neuronal cells. Biochem. Biophys. Res. Commun. 366, 520-525.
Van Wynsberghe, P.M., Chen, H.-R. and Ahlquist P. (2007) Nodavirus RNA replication protein A induces membrane association of genomic RNA. J.Virol. 81, 4633-4644.
Chen, C.-H., Yu, W.-C., Tsao, T. Y., Wang, L. Y., Chen, H.-R., Lin, J.-Y., Tsai, W.-Y. and Cheng, S.-C. (2002) Functional and physical interactions between components of the Prp19-associated complex. Nucleic Acid Res. 30, 1029-1037.
Chen, C.-H., Tsai, W.-Y., Chen, H.-R., and Cheng, S.-C. (2001) Identification and characterization of two novel component of the Prp19p-associated complex, Ntc30p and Ntc20p. J. Biol. Chem. 276, 488-494.
Sai, W.-Y., Chow, I.-T., Chen, H.-R., Huang, K.-T., Hong, R.-I., Jan, S.-P., Kuo, N.-Y., Tsao, T.-Y., Chen, C.-H. and Cheng, S.-C. (1999) Cef1p is a component of the Prp19p-associated complex and essential for pre-mRNA splicing. J. Biol. Chem. 274, 9455-9462.
Chen, H.-R., Tsao, T.-Y., Chen, C.-H., Tsai, W.-Y ., Her, L.-S., Hsu, M.-T. and Cheng, S.-C. (1999) Snt309p modulates interactions of Prp19p with its associated components to stabilize a protein complex essential for pre-mRNA splicing. Proc. Natl. Acad. Sci. USA 96, 5406-5411.
Chen, H.-R., Jan, S.-P., Tsao, T.- Y., Banroques Josette and Cheng S.-C. (1998) Snt309p, a component of the Prp19p-associated complex that interacts with Prp19p and associated with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p. Mol. Cell. Biol. 18, 2196-2204.
Chen, H.-R., Su, J.-C. and Sung, H.-Y. (1996) Mutation mechanism of some rice endosperm mutants elucidated by a comparative study of carbohydrate constituents. Proceedings of the National Science Council, ROC 20(1), 6-13.
Chen, H.-R., Hsu, M.-T. and Cheng, S.-C. (1995) Spheroplast preparation facilitates PCR screening of yeast sequence. BioTechniques 19, 744-747.
Tarn, W.-Y., Hsu, C.-H., Huang, K.-T., Chen, H.-R., and Kao, H.-Y., Lee, K.-R. and Cheng, S.-C. (1994) Functional association of essential splicing factor(s) with PRP19 in a protein complex. EMBO J. 13, 2421-2431.