Tel: (05)2720411 ext. Office 66503 Lab 61513

Fax: (05)2722871

Email: biohrc@ccu.edu.tw

• B.S., National Taiwan University, Agricultural Chemistry, 1985
• M.S., National Taiwan University, Institute of Agricultural Chemistry, 1987
• Ph.D., National Yang-Ming University, Institute of Microbiology and Immunology, 1998

• 2012.8-present Associate Professor, Department of Life Science, National Chung Cheng University
• 2002.2- 2012.7 Assistant Professor, Department of Life Science, National Chung Cheng University. Replication, infection and pathogenesis mechanisms of positive-strand RNA viruses.
• 2000.11-2002.1 Postdoctoral Fellow, with Dr. Paul Ahliquist, Institute for Molecular Virology, University of Wisconsin at Madison Purification of the RNA-dependent RNA polymerase complex of Flock House Virus (FHV) from yeast mitochondria.
• 1998.9-2000.10 Postdoctoral Fellow, with Dr. Soo-Chen Cheng (鄭淑珍), Institute of Molecular Biology, Academia Sinica. Characterization of protein factors in the Prp19p-associated complex.
• 1991.9-1998.8 Ph.D. Student, with Dr. Soo-Chen Cheng (鄭淑珍), Institute of Microbiology and Immunology, National Yang-Ming University. Establishment of genetic system to identify novel mRNA splicing factors in yeast.
• 1989.7-1991.8 Research Assistant, with Dr. Soo-Chen Cheng (鄭淑珍), Institute of Molecular Biology, Academia Sinica. Studies on mRNA splicing factors in yeast using biochemical approaches.
• 1987.7-1989.6 2nd Lieutenant, Military Service in Army.
• 1985.9-1987.6 Graduate Student, with Dr. Hsien-Yi Sung (宋賢一) and Jong-Ching Su (蘇仲卿), Laboratory of Biochemistry, Institute of Agricultural Chemistry, National Taiwan University. Research on carbohydrates metabolism in rice.
• 1984.9-1985.8 Undergraduate Student, with Dr. Hsien-Yi Sung (宋賢一) and Jong-Ching Su (蘇仲卿), Laboratory of Biochemistry, Department of Agricultural Chemistry, National Taiwan University. Research on enzyme purification in plants.

• 2006 九十四學年度中正大學全校優良導師獎
• 2006 九十四學年度中正大學教師優良教學獎
• 1998 Award of outstanding merit and high scholastic achievement in medical and pharmaceutical research sponsored by Wang Ming-Ning Memorial Foundation (王民寧優秀論文競賽獎)
• 1998 Award of excellent Ph. D. thesis sponsored by Dr. Chien-Tien Hsu (徐千田優秀論文競賽獎).

1. Lee, Y.-R., Wu, W.-C., Ji, W.-T., Chen, J.Y.-F., Cheng, Y.-P., Chiang, M.-K., and Chen, H.-R. (2012) Reversine suppresses oral squamous cell carcinoma via cell cycle arrest and concomitantly apoptosis and autophagy.  Journal of Biomedical Science   19:9
2. Nimje, V. R., Chen, C.-Y., Chen, H.-R.,  Chen, C.-C., Huang, Y.-M., Tseng, M.-J., Cheng, K.-C., & Chang, Y.-F. (2012) Comparative bioelectricity production from various wastewaters in microbial fuel cells using mixed cultures and a pure strain of Shewanella oneidensis.  Bioresour. Technol.  104:315-323.
3. Chiang, W.-F., Ho, H.-C., Chang, H.-Y., Chiu, C.-C., Chen, Y.-L., Hour, T.-C., Chuang, S.-J., Wu, Y.-J., Chen, H.-R.,  Chen, J.-H., Liu, S.-Y., Lu, C.-L. and Chen, J. Y.-F. Overexpression of Rho GDP-dissociation inhibitor alpha predicts poor survival in oral squamous cell carcinoma.  Oral Oncology  47: 452-458.
4. Nimje, V.-R., Chen, C.-Y., Chen, C.-C., Tsaib, J.-Y., Chen, H.-R.,  Huangd, Y.-M., Jean, J.-S., Chang, Y.-F. and Shih, R.-C. Microbial fuel cell of Enterobacter cloacae: Effect of anodic pH microenvironment on current,power density, internal resistance and electrochemical losses.  International Journal of Hydrogen Energy  36 (17):11093-11101.
5. Nimje, V. R., Chen, C.-Y., Chen, C.-C., Chen, H.-R.,  Tseng, M.-J., Jean, J.-S. & Chang, Y.-F. (2011) Glycerol degradation in single-chamber microbial fuel cells.  Bioresour. Technol.  Feb; 102, 2629-2634.
6. Jyoti Maity, Lin, T.-J., Cheng, P.-H., Chen, C.-Y., Reddy, A.-S., Atla, S.-B., Chang, Y.-F., Chen, H.-R.,  Chen, C.-C. Synthesis of brushite particles in reverse microemulsion of biosurfactant, surfactin.  International Journal of Molecular Sciences  12(6):3821-3830.
7. Chen, H.-R.,  Chen, C.-C., Reddy, A. S., Chen, C.-Y., Li, W. R., Tseng, M.-J., Liu, H.-T., Pan, W., Maity, J.P. & Atla, S.B. (2011) Removal of mercury by foam fractionation using surfactin, a biosurfactant.  Int. J. Mol. Sci.  12:8245-8258.
8. Huang, T.-T., Chen, J. Y.-F., Tseng, C.-E., Su, Y.-C., Ho, H.-C., Lee, M.-S., Chang, C.-T., Wong, Y.-K. and Chen, H.-R. (2010) Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan.  J Formos Med Assoc  109,326-337.
9. Tseng, M.-Y., Liu, S.-Y., Chen, H.-R.,  Wu, Y.-J., Chiu, C.-C., Chan, P.-T., Chiang, W.-F., Liu, Y.-C., Lu, C.-Y., Jou, Y.-S. and Chen, J. Y.-F. (2009) Serine protease inhibitor (SERPIN) B1 promotes oral cancer cell motility and is over-expressed in invasive oral squamous cell carcinoma.  Oral Oncol  45, 771-776.
10. Chen, J. Y.-F., Hung, C.-C., Huang, K.-L., Chen, Y.-T., Liu, S.-Y., Chiang, W.-F., Chen, H.-R.,  Yen, C.-Y., Wu, Y.-J., Ko, J.-Y. and Jou, Y.-S. (2008) Src family kinases mediate betel quid-induced oral cancer cell motility and could be a biomarker for early invasion in oral squamous cell carcinoma.  Neoplasia  10, 1393-1401.
11. Liu, S.-Y., Chen, Y.-T., Tseng, M.-Y., Hung, C.-C., Chiang, W.-F., Chen, H.-R., Shieh, T.-Y., Chen, C.-H., Jou, Y.-S. and Chen, J.Y.-F. (2008) Involvement of microtubule-associated protein 2 (MAP2) in oral cancer cell motility: A novel biological function of MAP2 in non-neuronal cells.  Biochem. Biophys. Res. Commun.  366, 520-525.
12. Van Wynsberghe, P.M., Chen, H.-R. and Ahlquist P. (2007) Nodavirus RNA replication protein A induces membrane association of genomic RNA.  J.Virol.  81, 4633-4644.
13. Chen, C.-H., Yu, W.-C., Tsao, T. Y., Wang, L. Y., Chen, H.-R., Lin, J.-Y., Tsai, W.-Y. and Cheng, S.-C. (2002) Functional and physical interactions between components of the Prp19-associated complex.  Nucleic Acid Res.  30, 1029-1037.
14. Chen, C.-H., Tsai, W.-Y., Chen, H.-R., and Cheng, S.-C. (2001) Identification and characterization of two novel component of the Prp19p-associated complex, Ntc30p and Ntc20p.  J. Biol. Chem.  276, 488-494.
15. Sai, W.-Y., Chow, I.-T., Chen, H.-R.,  Huang, K.-T., Hong, R.-I., Jan, S.-P., Kuo, N.-Y., Tsao, T.-Y., Chen, C.-H. and Cheng, S.-C. (1999) Cef1p is a component of the Prp19p-associated complex and essential for pre-mRNA splicing.  J. Biol. Chem.  274, 9455-9462.
16. Chen, H.-R.,  Tsao, T.-Y., Chen, C.-H., Tsai, W.-Y ., Her, L.-S., Hsu, M.-T. and Cheng, S.-C. (1999) Snt309p modulates interactions of Prp19p with its associated components to stabilize a protein complex essential for pre-mRNA splicing.  Proc. Natl. Acad. Sci. USA  96, 5406-5411.
17. Chen, H.-R.,  Jan, S.-P., Tsao, T.- Y., Banroques Josette and Cheng S.-C. (1998) Snt309p, a component of the Prp19p-associated complex that interacts with Prp19p and associated with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p.  Mol. Cell. Biol.  18, 2196-2204.
18. Chen, H.-R.,  Su, J.-C. and Sung, H.-Y. (1996) Mutation mechanism of some rice endosperm mutants elucidated by a comparative study of carbohydrate constituents. Proceedings of the National Science Council,  ROC  20(1), 6-13.
19. Chen, H.-R.,  Hsu, M.-T. and Cheng, S.-C. (1995) Spheroplast preparation facilitates PCR screening of yeast sequence.  BioTechniques  19, 744-747.
20. Tarn, W.-Y., Hsu, C.-H., Huang, K.-T., Chen, H.-R.,  and Kao, H.-Y., Lee, K.-R. and Cheng, S.-C. (1994) Functional association of essential splicing factor(s) with PRP19 in a protein complex.  EMBO J.  13, 2421-2431.