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國防大學國防醫學院免疫學博士

國立中正大學 生物醫學科學系 教授

• 2024/8  - 迄今       國立中正大學生物醫學科學系  教授兼系主任
• 2020/8 - present   國立中正大學 生物醫學科學系 教授
• 2011/8 - 2020/7     國立中正大學 生命科學系 副教授
• 2005/2 - 2011/7     國立中正大學 生命科學系 助理教授

免疫學、自體免疫疾病之機轉及治療之研究

本實驗室主要研究領域在自體免疫疾病致病機轉的探討及樹突狀細胞之研究。樹突狀細 胞是目前已知具最佳免疫調控能力之抗原呈現細胞(antigen presentation cell)。

探討第三誘餌蛋白質對自體免疫糖連病小鼠骨髓樹突狀細胞分化之調控。

「第三誘餌蛋白質(decoy receptor 3)」對自體免疫糖連病小鼠骨髓樹突狀細胞(bone marrow-derived dendritic cell)分化之調控；並以此方法發展出新型治療策略。樹突狀細胞是目前已知具最佳免疫調控能力之抗原呈現細胞(antigen presentation cell)，經三誘餌蛋白質處理過後之樹突狀細胞具有誘導T細胞走向第二型輔助性免疫反應(T-helper 2 immune response)之特性，恰好可以阻抗因第一型輔助性免疫反應(T-helper 1 immune response)所主導之自體免疫糖連病。本研究以昆蟲細胞系統(Sf21-bacculoexpressing system)生產並純化高品質第三誘餌蛋白質，並以此T細胞走向第二型輔助性免疫反應，且於細胞移植實驗(dendritic cell transfer experiment)中證實其免疫保護效果。另外更以先進之蛋白質體技術(proteeomic analysis)分析此誘餌蛋白對樹突狀細胞分化調控過程中各類基因細微之變化，此部分結果發表於 Journal of Leukocyte Biology 2004

延續過去的研究，未來亦將應用於另一種自體免疫疾病：多發性硬化症(multiple sclerosis)之研究。

1. CT Lin, CL Tung, YS Tai, YC Shen, SY Chen, MT Yu, Ch Ho and Wu, S.F. 2011 ,Prognostic relevance of preoperative circulating CD8-positive lymphocytes in the urinary bladder recurrence of urothelial carcinoma. Urologic Oncology . 2011 Mar 17. [Epub ahead of print]
2. Shen CH, Wu JD, Hsu CD, Jou YC, Lin CT, Wang M, Wu, S.F., Chan MW, Chiang MK, Fang CY, and Chang D. 2011. The high incidence of JC virus infection in urothelial carcinoma tissue in Taiwan.  Journal of Medical Virology  83:2191-9.
3. C.-Y. Fang, M. Wang, C.-Y. Fang, P.-L. Chen, Wu, S.F., M.-W.Y. Chan and D.C. Chang. 2011. Analysis of DNA methylation in human BK virus.  Virus Genes.  43, 201-207.
4. S.W. Huang, B.M.Hsu, Wu S.F., C.W.Fan, F.C. Shih, Y.C.Lin, and D.D.Ji. 2010. Water quality parameters associated with prevalence of Legionella in hot spring facility water bodies.  Water Res.  44:4805-4811.
5. Lin, C. T., M. T. Yu, C. Li, Y. C. Ho, C. H. Shen, D. W. Liu, D. C. Chang, and Wu, S.F.* 2010. Dysfunction of natural killer cells in patients with transitional cell carcinoma.  Cancer Lett  291:39-45.
6. Tung, C. L., P. H. Hou, Y. L. Kao, Y. W. Huang, C. C. Shen, Y. H. Cheng, Wu S.F., M. S. Lee, and C. Li. 2010. SOX2 modulates alternative splicing in transitional cell carcinoma.  Biochem Biophys Res Commun  393:420-42
7. Hsu, B. M., Wu, S.F., S. W. Huang, Y. J. Tseng, D. D. Ji, J. S. Chen, and F. C. Shih. 2010. Differentiation and identification of Shigella spp. and enteroinvasive Escherichia coli in environmental waters by a molecular method and biochemical test.  Water Res  44:949-955.
8. Lee, M.S., Huang, Y.H., Huang, S.P., Lin, R.I., Wu, S.F., Li, C. 2009. Identification of a nuclear localization signal in the polo box domain of Plk1.  Biochim Biophys Acta.  1793, 1571-8.
9. Chen, S. J., Y. L. Wang, J. H. Kao, S. F. Wu, W. T. Lo, C. C. Wu, P. L. Tao, C. C. Wang, D. M. Chang, and H. K. Sytwu. 2009. Decoy receptor 3 ameliorates experimental autoimmune encephalomyelitis by directly counteracting local inflammation and downregulating Th17 cells.  Mol Immunol  47:567-574.
10. Hung, J.T., Liao, J.H., Lin, Y.C., Chang, H.Y., Wu, S.F., Chang, T.H., Kung, J.T., Hsieh, S..L, McDevitt H, Sytwu, H.K. (2005) Immunopathogenic role of TH1 cells in autoimmune diabetes: evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model   J Autoimmun   25, 181-92. (SCI)
11. Wu, S.F., Liu, T. M., Lin, Y. C., Sytwu, H. K., Juan, S. F., Chen, S. T., Shen, K. L., Hsi, S. C., and Hsieh, S. L. (2004). Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone marrow-derived dendritic cells in nonobese diabetic mice: from regulatory mechanism to clinical implication.   J Leukoc Biol   75, 293-306. (SCI)
12. Wu, S.F., Liao, C. L., Lin, Y. L., Yeh, C. T., Chen, L. K., Huang, Y. F., Chou, H. Y., Huang, J. L., Shaio, M. F., and Sytwu, H. K. (2003). Evaluation of protective efficacy and immune mechanisms of using a non-structural protein NS1 in DNA vaccine against dengue 2 virus in mice.  Vaccine   21, 3919-3929. (SCI)
13. Wu, S.F., Lee, C. J., Liao, C. L., Dwek, R. A., Zitzmann, N., and Lin, Y. L. (2002). Antiviral effects of an iminosugar derivative on flavivirus infections.  J Virol  76, 3596-3604. (SCI)
14. Chen, S. L., Tsao, Y. P., Chen, Y. L., Huang, S. J., Chang, J. L., and Wu, S.F. (1998). The induction of apoptosis by SV40 T antigen correlates with c-jun overexpression.   Virology   244, 521-529.
15. Liang, S. C., Lin, S. Z., Yu, J. F., Wu, S.F., Wang, S. D., and Liu, J. C. (1997). F344-rnu/rnu athymic rats: breeding performance and acceptance of subcutaneous and intracranial xenografts at different ages.   Lab Anim Sci   47, 549-553.