Contact information 聯絡資訊

 Tel: (05)2720411 ext. Office 66516

 Fax: (05)2722871

 Email: seantsai@ccu.edu.tw

Academic qualication 學歷
  • 1993 - 1997  美國威斯康辛大學 博士
  • 1990 - 1992  美國東密西根大學 碩士
  • 1982 - 1986  國立成功大學 生物系 學士
Expertise 專長
  • 內分泌學、癌症及轉譯醫學、生物資訊學、表觀遺傳學、子宮內膜異位症
Current position 現職
  • 國立中正大學 校長 (2024/02 -  )  
  • 國立中正大學理學院生物醫學科學系 講座教授 (2024/02 -    )
  • 子宮內膜異位及子宮內膜期刊 編輯委員 (2023/01 - 迄今)
  • 分子內分泌學期刊 資深編輯委員 (2020/01-迄今)
  • 內分泌學期刊 資深編輯委員 (2020/01-迄今)
  • 生殖醫學及生物學期刊 編輯委員 (2018/01-迄今)
  • 中國生理學雜誌 編輯委員 (2018/01-迄今)
  • 實驗生物學及醫學期刊 亞洲區主編(2012/05-迄今)
Working Experience 經歷
  • 國立成功大學醫學院基礎醫學研究所 所長 (2020/08 - 2024/01)
  • 國立成功大學醫學院生理所 講座教授 (2019/08 - 2024/01)
  • 科技部 生命科學發展司 司長 (2014/07 - 2017/07)
  • 中國生理學會 理事長 (2016/05 - 2020/04)
  • 亞洲子宮內膜異位症學會 會長 (2019/01 - 2020/12)
  • 美國實驗生物學及醫學學會 理事(2018/05 - 2022/04)
  • 美國貝勒醫學大學 訪問學者 (2010/08 - 2011/07)
  • 國立成功大學醫學院生理所 特聘教授 (2008/08 - 2019/07)
  • 國立成功大學醫學院生理所 所長(2006/08 - 2009/07)
  • 國立成功大學醫學院生理所 教授(2005/08 - 2008/07)
  • 國立成功大學醫學院生理所 副教授(2002/08 - 2005/07)
  • 國立成功大學醫學院生理所 助理教授(1998/02 - 2002/07)
Research interest 研究興趣

 My research interests focus on understanding the molecular mechanisms of human diseases. Our studies could be divided into two areas:

  1. Endometriosis: Endometriosis is a common gynecological disease with the prevalence of 10-15 %. It is a complex disease with unknown etiology and severely reduces life quality of affected women and their family. We focus on local and epigenetic factors that cause inflammation in the peritoneal cavity, aberrant production of steroid hormones, angiogenesis, lymphangiogenesis, and suppression of immune function.
  2. Cancer: Drug resistance is the most critical issue that contributes to treatment failure and mortality. Hypoxia is one of the most critical factors contributing to drug resistance. However, mechanisms responsible for hypoxia-mediated increased in drug resistance remain largely unknown. We have employed systems biology approach to investigate effects of hypoxia-mediated gene regulatory networks in drug resistance and cancer malignancy. Current focuses are on the regulation of extracellular vesicles-mediated pancreatic cancer malignancy and TYRO3 nuclear function in colon cancer metastasis and drug resistance.
Achievement 特殊成就
  • 國際生理學聯盟 院士(2022)
  • 教育部 第65屆學術獎 (2022)
  • 美國生殖研究學會 傑出國際科學家獎(2021)
  • 美國癌症研究學會 最佳被引用論文(2019)
  • 科技部 傑出研究獎(2018)
  • 美國實驗生物醫學學會:會士(2018)
  • 美國實驗生物醫學學會 傑出科學家獎(2014)
  • 國科會 傑出研究獎(2011)
Publication 論文與著作
  1. HT Hou, TC Lin, MH Wu, SJ Tsai* Feel so bac: is Fusobacterium the suspect causing endometriosis? Trends Mol Med 29 (10):780-782, 2023.  https://doi.org/10.1016/j.molmed.2023.08.003.
  2. T Harada, F Taniguchi, SW Guo, YM Choi, KO Biberoglu, SJ Tsai, S Alborzi , M Al-Jefout, A Chalermchokcharoenkit, A Sison-Aguilar, YF Fong, H Senanayake, A Popov, A Hestiantoro, Y Kaufmann The Asian society of endometriosis and adenomyosis (ASEA) guidelines for managing adenomyosis. Reprod Med Biol 22(1): e12535, 2023. DOI: 10.1002/rmb2.12535
  3. CB Chu, CC Yang, YY Hsueh, PC Chen, YK Hong, YY Kuo, S-J Tsai* Aberrant expression of IL-17A in mast cells contributes to the pathogenesis of hidradenitis suppurativa. Br J Dermatol Aug 4:ljad273, 2023 DOI: 10.1093/bjd/ljad273
  4. SC Lin, WN Li, SC Lin, HT Hou, YC Tsai, TC Lin, MH Wu*, SJ Tsai* Targeting YAP1 ameliorates progesterone resistance in endometriosis. Hum Reprod 38 (6), 1124-1134, 1 June 2023. DOI: 10.1093/humrep/dead071
  5. PL Hsu, CW Chien, YA Tang, BW Lin, SC Lin, YS Lin, SY Chen, HS Sun*, SJ Tsai* Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. Sci Adv 9(15): eade3422, 12 Apr 2023. DOI: 10.1126/sciadv.ade3422.
  6. YS Lai CC Chang YY Chen TMH Nguyen J Xu YC Chen YF Chang CY Wang PS Chen SC Lin IC Peng SJ Tsai WT Chiu* Optogenetically engineered Ca2+ oscillation-mediated DRP1 activation promotes mitochondrial fission and cell death. J Cell Sci May 26, 2023. DOI: doi.org/10.1242/jcs.260819
  7. YY Chao, BM Huang, IC Peng, PR Lee, YS Lai, WT Chiu, YS Lin, SH Lin, JH Chang, PS Chen, SJ Tsai*, CY Wang* ATM-ATR-induced primary ciliogenesis promotes cisplatin resistance in pancreatic ductal adenocarcinoma. J Cell Physiol, 237(12):4487–4503, 2022.
  8. C.B. Chu, C.C. Yang, S.J. Tsai* Hidradenitis suppurativa: Disease pathophysiology and sex hormones. Chin J Physiol 64(6):257-265, Nov-Dec 2021, doi: 10.4103/cjp.cjp_67_21
  9. C.B. Chu, W.L. Li., S.H. Lin, C.K. Hsu, C.C. Yang*, S.J. Tsai* The influence of gender and smoking on hidradenitis suppurativa: A retrospective study of 161 patients in Taiwan. Dermatol Sin 39:125-31, 2021.
  10. C.B. Chu, C.C. Yang, S.J. Tsai* Global data analysis supports smoking as the fundamental element associated with geographic gender disparities in hidradenitis suppurativa. Br J Dermatol 185(5):1054-1056, June 2021 https://doi.org/10.1111/bjd.20581
  11. CA Wang, CF Li, RC Huang, PC Hou, JP Liou, SJ Tsai* Suppression of extracellular vesicle VEGF-C-mediated lymphangiogenesis and pancreatic cancer early dissemination by a selective HDAC1/2 inhibitor. Mol Cancer Ther 20(9):1550-1560; doi: 10.1158/1535-7163.MCT-20-0963, 2021.
  12. CA Wang, and SJ Tsai* Regulation of lymphangiogenesis by extracellular vesicles in cancer metastasis. Exp Biol Med (Maywood) 246(19):2048-2056, 2021
  13. PH Yu, PY Chou, WN Li, SJ Tsai, MH Wu* The pro-inflammatory and anti-inflammatory role of hyaluronic acid in endometriosis. Taiwan J Obstet Gynecol 60(4):711-717, July 2021
  14. IO Yusuf, HM Chen, PH Cheng, CY Chang, SJ Tsai, JI Chuang, CC Wu, BM Huang, HS Sun, CM Chen, SH Yang* FGF9 induces neurite outgrowth upon ERK signaling in knock-in striatal Huntington's disease cells. Life Sci 267, 118952, 2021 Feb 15.
  15. IO Yusuf, HM Chen, PH Cheng, CY Chang, SJ Tsai, JI Chuang, CC Wu, BM Huang, HS Sun, CM Chen, SH Yang* Fibroblast growth factor 9 stimulates neuronal length through NF-kB signaling in striatal cell Huntington’s disease models. Mol Neurobiol 58 (5): 2396-2406, May 2021.
  16. YS Lai, YH Chang, YY Chen, J Xu, CS Yu, SJ Chang, PS Chen, SJ Tsai, WT Chiu* Ca2+-regulated cell migration revealed by optogenetically engineered Ca2+ oscillations. J Cell Physiol 236(6):4681-4693, 2021 Jun. DOI: 10.1002/jcp.30190
  17. WN Li, MH Wu, SJ Tsai* HYPOXIA AND REPRODUCTIVE HEALTH: The role of hypoxia in the development and progression of endometriosis. Reproduction 161 (1): F19-F31, 2021. doi: 10.1530/REP-20-0267
  18. HC Lee, SC Lin, MH Wu, SJ Tsai* Inhibiting NTRK2 signaling causes endometriotic lesion regression. Reproduction 161(1):11-19, 2021 Jan; doi: 10.1530/REP-20-0163.
  19. YH Li, TM Chen, BM Huang, SH Yang, CC Wu, YM Lin, JI Chuang, SJ Tsai, HS Sun* FGF9 is a downstream target of SRY and sufficient to determine male sex fate in ex vivo XX gonad culture. Biol Reprod 103 (6):1300-1313, Dec 1, 2020
  20. WN Li, KY Hsiao, CA Wang, N Chang, PL Hsu, CH Sun, SR Wu, MH Wu*, SJ Tsai* Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune cells infiltration in endometriosis. Proc Natl Acad Sci USA 117 (41): 25859-25868, Oct 1, 2020 doi.org/10.1073/pnas.1920037117
  21. PS Chen, WT Chiu, PL Hsu, SC Lin, IC Peng, CY Wang, SJ Tsai* Pathophysiological implications of hypoxia in human diseases. J Biomed Sci 27: 63, 2020 May 11. doi.org/10.1186/s12929-020-00658-7
  22. S Koks*, RW Williams, J Quinn, F Farzaneh, N Conran, SJ Tsai, G Awandare, SR Goodman COVID-19: Time for precision epidemiology. Exp Biol Med (Maywood). 245 677-679. Apr 2020, DOI: 10.1177/1535370220919349
  23. CA Wang, YH Chang, PC Hou, YJ Tai, WN Li, PL Hsu, SR Wu, CF Li, YS Shan, SJ Tsai* DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination. J Extracell Vesicles 9 (1): 1746529, 2020 April 4. DOI: 10.1080/20013078.2020.1746529
  24. PS Chen, SC Lin, SJ Tsai* Complexity in regulating microRNA biogenesis in cancer. Exp Biol Med 245:395-401, 2020 March DOI: 10.1177/1535370220907314
  25. CH Lai, RY Chen, HP Hsieh, SJ Tsai, KC Chang, CJ Yen, YC Huang, YW Liu, JC Lee, YC Lai, LY Hung, BW Lin A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis. Cancer Lett 472:97-107, 2020 Mar 1; doi: 10.1016/j.canlet.2019.12.031.
  26. HC Lee, SC Lin, MH Wu*, SJ Tsai* Induction of pyruvate dehydrogenase kinase 1 by hypoxia alters cellular metabolism and inhibits apoptosis in endometriotic stromal cells. Reprod Sci 26 (6):734-744. doi: 10.1177/193371911878951, Jun; 2019.
  27. TM Chen, YH Chen, HS Sun, SJ Tsai* Fibroblast growth factors: Potential novel targets for regenerative therapy of osteoarthritis. Chin J Physiol 62:2-10, 2019 Feb
  28. TM Chen, MC Lai, YH Li, YL Chan, CH Wu, YM Wang, CW Chien, SY Huang, H. S Sun*, SJ Tsai* hnRNPM induces translation switch under hypoxia to promote colon cancer development. EBioMedicine 41:299-309 2019 March. PMID: 30852162, DOI: 10.1016/j.ebiom.2019.02.059
  29. PL Hsu, J Jou, SJ Tsai* TYRO3: a potential therapeutic target in cancer. Exp Biol Med 244: 83–9, 2019 Feb
  30. SC Lin, HC Lee, CT Hsu, YH Huang, WN Li, PL Hsu, MH Wu*, SJ Tsai* Targeting anthrax toxin receptor 2 ameliorates endometriosis progression. Theranostics; 9(3): 620-632, 2019. doi: 10.7150/thno.30655.
  31. MH Wu, KY Hsiao, SJ Tsai* Hypoxia: The force of endometriosis. J Obstet Gynaecol Res 45(3):532-541, 2019. doi: 10.1111/jog.13900.
  32. IO Yusuf, HM Chen, PH Cheng, CY Chang, SJ Tsai, JI Chuang, CC Wu, BM Huang, HS Sun, SH Yang* Fibroblast growth factor 9 activates anti-oxidative functions of Nrf2 through ERK signalling in striatal cell models of Huntington's disease. Free Radic Biol Med 130:256-266, 2019 Jan. DOI: 10.1016/j.freeradbiomed.2018.10.455