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校長

SHAW-JENQ(Sean), TSAI

Contact information 聯絡資訊

 Tel: (05)2720411 ext. Office 66516

 Fax: (05)2722871

 Email: seantsai@ccu.edu.tw

Academic qualication 學歷
  • 1993 - 1997  美國威斯康辛大學 博士
  • 1990 - 1992  美國東密西根大學 碩士
  • 1982 - 1986  國立成功大學 生物系 學士
Expertise 專長
  • 內分泌學、癌症及轉譯醫學、生物資訊學、表觀遺傳學、子宮內膜異位症
Current position 現職
  • 國立中正大學 校長 (2024/02 -  )  
  • 國立中正大學理學院生物醫學科學系 講座教授 (2024/02 -    )
  • 子宮內膜異位及子宮內膜期刊 編輯委員 (2023/01 - 迄今)
  • 分子內分泌學期刊 資深編輯委員 (2020/01-迄今)
  • 內分泌學期刊 資深編輯委員 (2020/01-迄今)
  • 生殖醫學及生物學期刊 編輯委員 (2018/01-迄今)
  • 中國生理學雜誌 編輯委員 (2018/01-迄今)
  • 實驗生物學及醫學期刊 亞洲區主編(2012/05-迄今)
Working Experience 經歷
  • 國立成功大學醫學院基礎醫學研究所 所長 (2020/08 - 2024/01)
  • 國立成功大學醫學院生理所 講座教授 (2019/08 - 2024/01)
  • 科技部 生命科學發展司 司長 (2014/07 - 2017/07)
  • 中國生理學會 理事長 (2016/05 - 2020/04)
  • 亞洲子宮內膜異位症學會 會長 (2019/01 - 2020/12)
  • 美國實驗生物學及醫學學會 理事(2018/05 - 2022/04)
  • 美國貝勒醫學大學 訪問學者 (2010/08 - 2011/07)
  • 國立成功大學醫學院生理所 特聘教授 (2008/08 - 2019/07)
  • 國立成功大學醫學院生理所 所長(2006/08 - 2009/07)
  • 國立成功大學醫學院生理所 教授(2005/08 - 2008/07)
  • 國立成功大學醫學院生理所 副教授(2002/08 - 2005/07)
  • 國立成功大學醫學院生理所 助理教授(1998/02 - 2002/07)
Research interest 研究興趣

 My research interests focus on understanding the molecular mechanisms of human diseases. Our studies could be divided into two areas:

  1. Endometriosis: Endometriosis is a common gynecological disease with the prevalence of 10-15 %. It is a complex disease with unknown etiology and severely reduces life quality of affected women and their family. We focus on local and epigenetic factors that cause inflammation in the peritoneal cavity, aberrant production of steroid hormones, angiogenesis, lymphangiogenesis, and suppression of immune function.
  2. Cancer: Drug resistance is the most critical issue that contributes to treatment failure and mortality. Hypoxia is one of the most critical factors contributing to drug resistance. However, mechanisms responsible for hypoxia-mediated increased in drug resistance remain largely unknown. We have employed systems biology approach to investigate effects of hypoxia-mediated gene regulatory networks in drug resistance and cancer malignancy. Current focuses are on the regulation of extracellular vesicles-mediated pancreatic cancer malignancy and TYRO3 nuclear function in colon cancer metastasis and drug resistance.
Achievement 特殊成就
  • 國際生理學聯盟 院士(2022)
  • 教育部 第65屆學術獎 (2022)
  • 美國生殖研究學會 傑出國際科學家獎(2021)
  • 美國癌症研究學會 最佳被引用論文(2019)
  • 科技部 傑出研究獎（2018）
  • 美國實驗生物醫學學會 會士(2018)
  • 美國實驗生物醫學學會 傑出科學家獎(2014)
  • 國科會 傑出研究獎（2011）
Publication 論文與著作
  1.  SC Lin, WN Li, SC Lin, HT Hou, YC Tsai, TC Lin, MH Wu*, SJ Tsai* Targeting YAP1 ameliorates progesterone resistance in endometriosis. Hum Reprod Apr 18, 2023. DOI: 10.1093/humrep/dead071
  2. PL Hsu, CW Chien, YA Tang, BW Lin, SC Lin, YS Lin, SY Chen, HS Sun*, SJ Tsai* Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. Sci Adv 9(15): eade3422, Apr 12 2023. DOI: 10.1126/sciadv.ade3422.
  3.  YS Lai, CC Chang, YY Chen, TMH Nguyen, J Xu, YC Chen, YF Chang, CY Wang, PS Chen, SC Lin, IC Peng, SJ Tsai, WT Chiu* Optogenetically engineered Ca2+ oscillation-mediated DRP1 activation promotes mitochondrial fission and cell death. J Cell Sci May 26, 2023. DOI: doi.org/10.1242/jcs.260819.
  4. YY Chao, BM Huang, IC Peng, PR Lee, YS Lai, WT Chiu, YS Lin, SH Lin, JH Chang, PS Chen, SJ Tsai*, CY Wang* ATM-ATR-induced primary ciliogenesis promotes cisplatin resistance in pancreatic ductal adenocarcinoma. J Cell Physiol, 237:4487–4503, 2022.
  5. C.B. Chu, C.C. Yang, S.J. Tsai* Hidradenitis suppurativa: Disease pathophysiology and sex hormones. Chin J Physiol 64(6):257-265, Nov-Dec 2021.
  6. C.B. Chu, W.L. Li., S.H. Lin, C.K. Hsu, C.C. Yang*, S.J. Tsai* The influence of gender and smoking on hidradenitis suppurativa: A retrospective study of 161 patients in Taiwan. Dermatol Sin 39:125-31, 2021.
  7. C.B. Chu, C.C. Yang, S.J. Tsai* Global data analysis supports smoking as the fundamental element associated with geographic gender disparities in hidradenitis suppurativa. Br J Dermatol 185(5):1054-1056, June 2021
  8. CA Wang, CF Li, RC Huang, PC Hou, JP Liou, SJ Tsai* Suppression of extracellular vesicle VEGF-C-mediated lymphangiogenesis and pancreatic cancer early dissemination by a selective HDAC1/2 inhibitor. Mol Cancer Ther 20(9):1550-1560; 2021.
  9. CA Wang, and SJ Tsai* Regulation of lymphangiogenesis by extracellular vesicles in cancer metastasis. Exp Biol Med (Maywood) 246(19):2048-2056, 2021
  10. PH Yu, PY Chou, WN Li, SJ Tsai, MH Wu* The pro-inflammatory and anti-inflammatory role of hyaluronic acid in endometriosis. Taiwan J Obstet Gynecol 60(4):711-717, July 2021
  11. IO Yusuf, HM Chen, PH Cheng, CY Chang, SJ Tsai, JI Chuang, CC Wu, BM Huang, HS Sun, CM Chen, SH Yang* FGF9 induces neurite outgrowth upon ERK signaling in knock-in striatal Huntington's disease cells., Life Sci 267, 118952, Feb 15 2021.
  12. IO Yusuf, HM Chen, PH Cheng, CY Chang, SJ Tsai, JI Chuang, CC Wu, BM Huang, HS Sun, CM Chen, SH Yang* Fibroblast growth factor 9 stimulates neuronal length through NF-kB signaling in striatal cell Huntington’s disease models. Mol Neurobiol 58 (5): 2396-2406, May 2021.
  13. YS Lai, YH Chang, YY Chen, J Xu, CS Yu, SJ Chang, PS Chen, SJ Tsai, WT Chiu* Ca2+-regulated cell migration revealed by optogenetically engineered Ca2+ oscillations. J Cell Physiol 236(6):4681-4693, June 2021.
  14. WN Li, MH Wu, SJ Tsai* HYPOXIA AND REPRODUCTIVE HEALTH: The role of hypoxia in the development and progression of endometriosis. Reproduction 161 (1): F19-F31, 2021.
  15. HC Lee, SC Lin, MH Wu, SJ Tsai* Inhibiting NTRK2 signaling causes endometriotic lesion regression. Reproduction 161(1):11-19, January 2021.
  16. YH Li, TM Chen, BM Huang, SH Yang, CC Wu, YM Lin, JI Chuang, SJ Tsai, HS Sun* FGF9 is a downstream target of SRY and sufficient to determine male sex fate in ex vivo XX gonad culture. Biol Reprod 103 (6):1300-1313, Dec 1, 2020
  17. WN Li, KY Hsiao, CA Wang, N Chang, PL Hsu, CH Sun, SR Wu, MH Wu*, SJ Tsai* Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune cells infiltration in endometriosis. Proc Natl Acad Sci USA 117 (41): 25859-25868, Oct 1, 2020.
  18. PS Chen, WT Chiu, PL Hsu, SC Lin, IC Peng, CY Wang, SJ Tsai* Pathophysiological implications of hypoxia in human diseases. J Biomed Sci 27: 63, May 11 2020.
  19. S Koks*, RW Williams, J Quinn, F Farzaneh, N Conran, SJ Tsai, G Awandare, SR Goodman COVID-19: Time for precision epidemiology. Exp Biol Med (Maywood). 245 677-679. Apr 2020,
  20. CA Wang, YH Chang, PC Hou, YJ Tai, WN Li, PL Hsu, SR Wu, CF Li, YS Shan, SJ Tsai* DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination. J Extracell Vesicles 9 (1): 1746529, April 4 2020.
  21. PS Chen, SC Lin, SJ Tsai* Complexity in regulating microRNA biogenesis in cancer. Exp Biol Med 245:395-401, March 2020.
  22. CH Lai, RY Chen, HP Hsieh, SJ Tsai, KC Chang, CJ Yen, YC Huang, YW Liu, JC Lee, YC Lai, LY Hung*, BW Lin* A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis. Cancer Lett 472:97-107, Mar 1 2020.
  23. HC Lee, SC Lin, MH Wu*, SJ Tsai* Induction of pyruvate dehydrogenase kinase 1 by hypoxia alters cellular metabolism and inhibits apoptosis in endometriotic stromal cells. Reprod Sci 26 (6):734-744. doi: 10.1177/193371911878951, Jun; 2019.
  24. TM Chen, YH Chen, HS Sun, SJ Tsai* Fibroblast growth factors: Potential novel targets for regenerative therapy of osteoarthritis. Chin J Physiol 62:2-10, Feb 2019.
  25. TM Chen, MC Lai, YH Li, YL Chan, CH Wu, YM Wang, CW Chien, SY Huang, H. S Sun*, SJ Tsai* hnRNPM induces translation switch under hypoxia to promote colon cancer development. EBioMedicine 41:299-309, March 2019.
  26. PL Hsu, J Jou, SJ Tsai* TYRO3: a potential therapeutic target in cancer. Exp Biol Med 244: 83–9, Feb 2019
  27. SC Lin, HC Lee, CT Hsu, YH Huang, WN Li, PL Hsu, MH Wu*, SJ Tsai* Targeting anthrax toxin receptor 2 ameliorates endometriosis progression. Theranostics; 9(3): 620-632, 2019.
  28. MH Wu, KY Hsiao, SJ Tsai* Hypoxia: The force of endometriosis. J Obstet Gynaecol Res 45(3):532-541, 2019.
  29. IO Yusuf, HM Chen, PH Cheng, CY Chang, SJ Tsai, JI Chuang, CC Wu, BM Huang, HS Sun, SH Yang* Fibroblast growth factor 9 activates anti-oxidative functions of Nrf2 through ERK signalling in striatal cell models of Huntington's disease. Free Radic Biol Med 130:256-266, January 2019.
  30. JL Fu, KY Hsiao, HC Lee, WN Li, N Chang, MH Wu*, SJ Tsai* Suppression of COUP-TFII upregulates angiogenin and promotes angiogenesis in endometriosis. Hum Reprod 33 (8): 1517-27, Aug 1 2018.
  31. DM Brown, HC Lee, S Liu, CM Quick, LM Fernandes, FA Simmen, SJ Tsai, RCM Simmen* Notch-1 Signaling activation and progesterone receptor expression in ectopic lesions of women with endometriosis. J Endocr Soc 2 (7): 765-78, July 1 2018.
  32. IO Yusuf, PH Cheng, HM Chen, YF Chang, CY Chang, HI Yang, CW Lin, SJ Tsai, JI Chuang, CC Wu, BM Huang, HS Sun, SH Yang* Fibroblast Growth Factor 9 Suppresses Striatal Cell Death Dominantly Through ERK Signaling in Huntington's Disease. Cell Physiol Biochem 48(2):605-617, August 2018.
  33. WN Li, MH Wu, SJ Tsai* Critical factors involved in chronic inflammation in the pathophysiology of endometriosis. Adaptive Medicine 10 (1):1-9, 2018
  34. KY Hsiao, HS Sun, SJ Tsai* Circular RNA - New member of noncoding RNA with novel functions. Exp Biol Med (Maywood) 242(11):1136-1141, 2017
  35. SC Lin, HC Lee, PC Hou, JL Fu, MH Wu, SJ Tsai* Targeting hypoxia-mediated YAP1 nuclear translocation ameliorates pathogenesis of endometriosis without compromising maternal fertility. J Pathol 242: 476–487, 2017 (Cover of the issue)
  36. KY Hsiao, N Chang, JL Tsai, SC Lin, SJ Tsai, MH Wu* Hypoxia-inhibited dual specificity phosphatase-2 promotes IL-6/STAT3 signaling in endometriosis. Am J Reprod Immunol 78:e12690, 2017.
  37. KY Hsiao, MH Wu, SJ Tsai* Epigenetic regulation of the pathological process in endometriosis. Reprod Med Biol 16(4):314-319 July 23 2017.
  38. HC Lee, SJ Tsai* Hypoxia: endocrine targets of hypoxia-inducible factors. J Endocrinol 234(1): R53-R65, 2017
  39. PC Hou, YH Li, SC Lin, SC Lin, JC Lee, BW Lin, JP Liou, JY Chang, CC Kuo, YM Liu, HS Sun, SJ Tsai* Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness. Cancer Res, 77 (16): 4305-4316, 2017
  40. KY Hsiao, YC Lin, SK Gupta, N Chang, L Yen, H. S Sun*, SJ Tsai* Noncoding effects of circular RNA CCDC66 promote colon cancer growth and metastasis. Cancer Res 77:2339-2350. May 1, 2017 (Hot paper, high-cite paper, Most-cited articles in 2017)
  41. SC Lin, KY Hsiao, N Chang, PC Hou, SJ Tsai* Loss of dual specificity phosphatase-2 promotes angiogenesis and metastasis via upregulation of interleukin-8 in colon cancer. J Pathol 241: 638–648, 2017
  42. SC Lin, CY Kao, HJ Lee, C Creighton, M Ittmann, SJ Tsai, S Tsai*, and MJ Tsai* Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nat Commun 7:11418, 2016
  43. CW Chien, PC Ho, HC Wu, YL Chang, SC Lin, BW Lin, JC Lee, YJ Chang, HS Sun, SJ Tsai* Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer. Oncogene 35(45):5872-5881, 2016
  44. MS Lai, CY Wang, SH Yang, CC Wu, HS Sun, SJ Tsai, JI Chuang, YC Chen, BM Huang* The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes. Organogenesis 12(2):61-77, 2016.
  45. KY Hsiao, MH Wu, N Chang, SH Yang, CW Wu, HS Sun, SJ Tsai* Coordination of AUF1 and miR-148a to destabilize DNA methyltransferase 1 mRNA under hypoxia in endometriosis. Mol Hum Reprod 21:894-904, 2015
  46. JI Chuang, JY Huang, SJ Tsai, HS Sun, SH Yang, PC Chuang, BM Huang, CH Ching* FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation. Free Radic Biol Med 89:274-286, 2015
  47. MH Fu, CL Li, HL Lin, SJ Tsai, YY Lai, YF Chang, PH Cheng, CM Chen, SH Yang* The potential regulatory mechanisms of miR-196a in Huntington's disease through bioinformatic analyses. PLoS One, 10(9):e0137637, 2015.
  48. KC Liang, JT Tseng, SJ Tsai, HS Sun* Characterization and distribution of repetitive elements in association with genes in the human genome. Comput Biol Chem, 57:29-38, 2015
  49. MH Wu, KY Hsiao, SJ Tsai* Endometriosis and possible inflammation markers. Gynecol Minim Invasive Ther 4:61-67, 2015.
  50. CA Wang, SJ Tsai* 2015 The non-canonical role of vascular endothelial growth factor-C axis in cancer progression. Exp Biol Med (Maywood) 240(6):718-24, 2015
  51. KY Hsiao, SC Lin, MH Wu*, SJ Tsai* Pathological functions of hypoxia in endometriosis. Front Biol Sci 7: 309-321, 2015
  52. SC Lin, WL Liao, JC Lee, SJ Tsai* Hypoxia-regulated gene network in drug resistance and cancer progression. Exp Biol Med 239:779-792, 2014
  53. WL Liao, SC Lin, HS Sun, and SJ Tsai* Hypoxia-induced tumor malignancy and drug resistance: The role of microRNAs. Biomarkers Genomic Med 6:1-11, 2014
  54. MS Lai, YS Cheng, PR Chen, SJ Tsai, BM Huang* Fibroblast growth factor 9 activates Akt and MAPK pathways to stimulate steroidogenesis in mouse Leydig cells. PLoS One 9(3): e90243, 2014
  55. SC Lin, YH Li, MH Wu, YF Chang, DK Lee, S Tsai, MJ Tsai, and SJ Tsai* Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis. J Clin Endocrinol Metab 99(3): E427-37, 2014.
  56. TM Chen, YH Shih, JT Tseng, MC Lai, Ch Wu, YH Li, SJ Tsai*, and HS Sun* Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation. Nucleic Acids Res 42:2932-44, 2014
  57. YT Tang, HY Kao, SJ Tsai, HC Wang A* semi-supervised, weighted pattern-learning approach for extraction of gene regulation relationships from scientific literature. Int J Data Min Bioinform 9 (4): 401-416, 2014.
  58. HC Wang*, TK Kooi, HY Kao, SC Lin, SJ Tsai Using positive and negative patterns to extract information from journal articles regarding the regulation of a target gene by a transcription factor. Computers Biol Med, 43:2214-21, 2013
  59. SP Wu, CM Cheng, W Chen, T Wang, JL Respress, S Ather, RB Lanz, SJ Tsai, XHT Wehrens, MJ Tsai*, and SY Tsai* Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell 25, 417-426, 2013.
  60. HM Chen, YH Lin, YM Cheng, LYC Wing, SJ Tsai* Overexpression of integrin-β1 promotes leiomyomal cell spreading and proliferation. J Clin Endocrinol Metab 98:E837-46, 2013.
  61. PH Cheng, CL Li, YF Chang, SJ Tsai, YY Lai, AW Chan, CM Chen, SH Yang* miR-196a Ameliorates Phenotypes of Huntington Disease in Cell, Transgenic Mouse, and Induced Pluripotent Stem Cell Models. Am J Hum Genet 93: 306-312, 2013.
  62. MC Lai, SW Wang, L Cheng, WY Tarn, SJ Tsai*, HS Sun* Human DDX3 interacts with the HIV-1 Tat protein to facilitate viral mRNA translation. PLoS ONE 8(7): e68665, 2013.
  63. MH Wu, PC Chuang, YJ Lin, SJ Tsai* Suppression of annexin A2 by prostaglandin E2 impairs phagocytic ability of peritoneal macrophage in women with endometriosis. Hum Reprod 28:1045-53, 2013 (recommended by Faculty 1000 of Medicine)
  64. J Qin, SP Wu, F Dai, X Xie, CM Cheng, C J Creighton, A Frolov, Gustavo Ayala, X Lin, XH Feng, MM Ittmann, SJ Tsai, MJ Tsai*, SY Tsai* Inhibition of TGF-β-dependent growth barrier by COUP-TFII to promote prostate tumor growth and metastasis. Nature 493: 236-240, 2013
  65. JS Chen, WS Hung, HH Chan, SJ Tsai, and HS Sun* In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma. Bioinformatics 29:420-7, 2012
  66. CC Wang, SC Lin, YH Lee, SJ Tsai* Hypoxia-induced tumor progression and drug resistance: from current understandings to future perspectives. Adaptive Med 4: 132-44, 2012.
  67. SC Lin, CC Wang, MH Wu, HS Yang, YH Lee, SJ Tsai* Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells. J Clin Endocrinol Metab 97: E1515–E1523, 2012.
  68. MC Wiltbank*, SM Salih, MO Atli, W Luo, CL Bormann, JS Ottobre, CM Vezina, V Mehta, FJ Diaz, SJ Tsai, R Sartori Comparison of endocrine and cellular mechanisms regulating the corpus luteum of primates and ruminants. Anim Reprod, 9(3), 242-259, 2012.
  69. MW Lin, SJ Tsai, PY Chou, MF Huang, HS Sun, MH Wu* Vitamin D receptor 1a promoter -1521G/C and -1012 A/G polymorphisms in polycystic ovary syndrome. Taiwan J Obstet Gynecol, 51(4), 565-571, 2012.
  70. MH Wu, CW Lu, FM Chang, SJ Tsai* Estrogen receptor expression affected by hypoxia inducible factor-1α in stromal cells from patients with endometriosis Taiwan J Obstet Gynecol 51: 50-54, 2012.
  71. MH Wu, SC Lin, KY Hsiao, and SJ Tsai* Hypoxia-inhibited dual specificity phosphatase-2 expression in endometriotic cells regulates cyclooxygenase-2 expression. J Pathol 225: 390-400, 2011 (recommended by Faculty 1000 of Medicine)
  72. CW Lu, SC Lin, CW Chien, SC Lin, CT Lee, BW Lin, JC Lee, and SJ Tsai* Overexpression of pyruvate dehydrogenase kinase-3 increases drug resistance and predicts poor prognosis of colon cancer. Am J Pathol 179: 1405-11, 2011
  73. SC Lin, CW Chien, JC Lee, YC Yeh, KF Hsu, YY Lai, SC Lin, and SJ Tsai* Suppression of dual specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells. J Clin Invest 121: 1905-1916, 2011
  74. YS Lin, SJ Tsai, MW Lin, CT Yang, MF Huang, MH Wu* Interleukin-6 as an early chronic inflammatory marker in polycystic ovary syndrome with insulin receptor substrate-2 polymorphism. Am J Reprod Immunol 66: 527–533, 2011
  75. HC Wang, YS Chen, HY Kao, SJ Tsai* Inference of transcriptional regulatory network by bootstrapping patterns. Bioinformatics 27:1422-1428. 2011
  76. YT Tang, SJ Li, HY Kao, SJ Tsai, HC Wang* Using unsupervised patterns to extract gene regulation relationships for network construction. PLoS ONE 6: e19633, 2011
  77. IW Teng, PC Hou, KD Lee, PY Chu, KT Yeh, V Jin, MJ Tseng, SJ Tsai, YS Chang, CS Wu, HS Sun, KD Tsai, LB Jeng, KP Nephew, THM Huang, YW Leu*, SH Hsiao* Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells. Cancer Res 71:4653-4663, 2011
  78. TM Chen, CH Hsu, SJ Tsai*, HS Sun* AUF1 p42 isoform selectively controls both steady-state and PGE2-induced FGF9 mRNA decay. Nucleic Acids Res 38:8061-8071, 2010.
  79. SH Hsiao, KD Lee, CC Hsu, MJ Tseng, V Jin, WS Sun, YC Hung, KT Yeh, P Yan, YY Lai, HS Sun, YJ Lu, YS Chang, SJ Tsai, T Huang, YW Lu* DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination. Biochem Biophys Res Com 400:305-312, 2010.
  80. PC Chuang, YJ Lin, MH Wu, LYC Wing, Y Shoji, and SJ Tsai* Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis Am J Pathol 176:850-860, 2010. (recommended by Faculty 1000 of Medicine)
  81. MH Wu, MF Huang, FM Chang, SJ Tsai* Leptin on peritoneal macrophages of patients with endometriosis. Am J Reprod Immunol 63:214-221, 2010
  82. W Chen, SJ Tsai*, HM Sheu, CC Zouboulis Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone Exp Dermatol 19:470-472, 2010.
  83. YM Lin, CC Tsai, CL Chung, HS Sun, SJ Tsai*, BM Huang* Fibroblast growth factor 9 stimulates steroidogenesis in postnatal Leydig cells. Intl J Androl 33:545-553, 2010.
  84. MH Wu, CW Lu, PC Chuang, SJ Tsai* 2010 Prostaglandin E2: the master of endometriosis? Exp Biol Med 235: 668-677. (recommended by Faculty 1000 of Medicine)
  85. Chuang PC, Wu MH, Shoji Y, and Tsai SJ* Downregulation of CD36 results in reduced phagocytic ability of peritoneal macrophages of women with endometriosis. J Pathol 219:232-241, 2009.
  86. W Chen, SJ Tsai*, CA Wang, JC Tsai, CC Zouboulis Human sebocytes express prostaglandin E2 receptors EP2 and EP4 but treatment with prostaglandin E2 does not affect testosterone production. Br J Dermatol 161:674-677, 2009.
  87. HA Pan, YC Lee, YN Teng, SJ Tsai, YM Lin, PL Kuo* CDC25 protein expression and interaction with DAZL in human corpus luteum. Fertil Steril 92:1997-2003, 2009.
  88. CW Lu, SC Lin, KF Chen, YY Lai, and SJ Tsai* Induction of pyruvate dehydrogenase kinase 3 by hypoxia promotes metabolic switch and drug resistance of cancer cells. J Biol Chem 283:28106-28114 2008.
  89. CW Chien, SC Lin, YY Lai, PW Lin, SC Lin, JC Lee*, and SJ Tsai* Regulation of CD151 by hypoxia controls cell adhesion and metastasis in colorectal cancer. Clin Cancer Res 14:8043-8051, 2008.
  90. CC Hsu, CW Lgu, BM Huang, MH Wu, and SJ Tsai* Cyclic adenosine 3, 5-monophosphate response element-binding protein and CCAAT/enhancer-binding protein mediate prostaglandin E2-induced steroidogenic acute regulatory protein expression in endometriotic stromal cells. Am J Pathol 173:433-441, 2008.
  91. CY Yang, YJ Wang, PC Chen, SJ Tsai, YL Guo* Exposure to a mixture of polychlorinated biphenyls and polychlorinated dibenzofurans resulted in a prolonged time to pregnancy in women. Environmental health perspectives 116: 599-604, 2008.
  92. WC Chen*, CC Yang, RY Tsai, CY Liao, YT Yen, CL Hung, KF Chen, SJ Tsai, CC Zouboulis. Expression of sex-determining genes in the scalp of men with androgenetic alopecia. Dermatology 214:199-204, 2007.
  93. HH Chan, SJ Tsai, HS Sun* TAG: a comprehensive database for cancer research. Nucleic Acids Res Molecular Biology Database Collection # 922, 2007.
  94. MH Wu, KF Chen, SJ Lin, CW Lgu, and SJ Tsai* Aberrant expression of leptin in human endometriotic stromal cells is induced by elevated levels of hypoxia inducible factor-1α. Am J Pathol 170:590-598, 2007
  95. TM Chen, PL Kuo, CH Hsu, SJ Tsai, MJ Chen, CW Lin, HS Sun* Microsatellite in the 3’ untranslated region of human fibroblast growth factor 9 (FGF9) gene exhibits pleiotropic effect on modulating FGF9 protein expression. Hum Mutation 28:98, 2007.
  96. MH Wu, Y Shoji, PC Chuang, and SJ Tsai* Endometriosis: disease pathophysiology and the role of prostaglandins. Expert Rev Mol Med. 2007 January 16;9(2):1-20, 2007.
  97. PC Chuang, HS Sun, TM Chen, and SJ Tsai* Prostaglandin E2 induces fibroblast growth factor-9 via EP3 dependent PKCδ and Elk-1 signaling. Mol. Cell. Biol 26:8281-8292, 2006.
  98. WC Chen*, CC Yang, CY Liao, CL Hung, SJ Tsai, KF Chen, HM Sheu, and CC Zouboulis Expression of sex-determining genes in human sebaceous glands and their possible role in the pathogenesis of acne. J Eur Acad Dermatol Venereol 20:846-852, 2006.
  99. WC Chen*, SJ Tsai, CY Liao, RY Tsai, YJ Chen, BJ Pan, CL Hung and CC Zouboulis Higher levels of steroidogenic acute regulatory protein and type I 3β-hydroxysteroid dehydrogenase in the scalp of men with androgenetic alopecia. J Invest Dermatol 126, 2332-2335, 2006.
  100. YF Chen, PL Kou, SJ Tsai, KF Chen, HH Chan, CM Chen, HS Sun* Computational analysis and refinement of sequence structure on chromosome 22q11.2 region: application to the development of quantitative real-time PCR assay for clinical diagnosis Genomics 87:290-297, 2006.
  101. KF Chen, YY Lai, HS Sun, and SJ Tsai* Transcriptional repression of human cad gene by hypoxia inducible factor-1α. Nucleic Acids Res 33:5190-5198, 2005.
  102. MH Wu, Y Shoji, MC Wu, PC Chuang, CC Lin, MF Huang, SJ Tsai* Suppression of matrix metalloproteinase-9 by prostaglandin E2 in peritoneal macrophage is associated with severity of endometriosis. Am J Pathol 167:1061-1069, 2005.
  103. SJ Tsai, SJ Lin, YM Cheng, LYC Wing* Expression and functional analysis of pituitary tumor transforming gene-1 in uterine leiomyoma J Clin Endocrinol Metab 90:3715-3723, 2005.
  104. LYC Wing, SM Chen, PC Chuang, MH Wu, SJ Tsai* The mTOR-S6K1 but not PI3K-Akt signaling is responsible for fibroblast growth factor-9-induced cell proliferation J Biol Chem 280: 19937-19947, 2005.
  105. WC Chen*, GY Chen, SJ Tsai, PW Wang, HM Sheu, YS Shen, FF Chen Mild cutaneous manifestation in two young women with extraordinary hyperandrogenemia. Dermatology 210:49-52, 2005.
  106. MH Wu, CA Wang, CC Lin, LC Chen, WC Chang, and SJ Tsai* Distinct regulation of cyclooxygenase-2 by interleukin-1β in normal and endometriotic stromal cells. J Clin Endocrinol Metab 90: 286-295, 2005.
  107. BM Huang, KY Hsiao, PC Chuang, MH Wu, HA Pan, and SJ Tsai* Upregulation of steroidogenic enzymes and ovarian 17β-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium Biol Reprod 70:1358-1364, 2004.
  108. MH Wu*, MF Huang, SJ Tsai, HA Pan, YC Cheng, YS Lin Effects of laparoscopic ovarian drilling on young adult women with polycystic ovarian syndrome. J Am Assoc Gynecol Laparosc 11:184-90, 2004.
  109. S Ip, T Wong, SJ Tsai, P Leung* The recovery of some components of the renin angiotensin system in the rat pancreas after chronic exposure to hypoxic condition. J Mol Endocrinol 31:563-571, 2003.
  110. JLM Vasconcelos, S Sangsritavong, SJ Tsai, MC Wiltbank* Acute reduction in serum progesterone concentrations after feed intake in dairy cows. Theriogenology 60: 795-807, 2003.
  111. LC Wing, PC Chuang, MH Wu, C HM hen, and SJ Tsai* Expression and mitogenic effect of fibroblast growth factor -9 in human endometriotic implant is regulated by aberrant production of estrogen. J Clin Endocrinol Metab 88: 5547-5554, 2003.
  112. HS Sun, KY Hsiao, CC Hsu, MH Wu, and SJ Tsai* Transactivation of steroidogenic acute regulatory protein in human endometriotic stromal cells is mediated by the prostaglandin EP2 receptor. Endocrinology 144:9 3934-3942, 2003.
  113. CC Hsu, YL Huang, SJ Tsai, CC Sheu, BM Huang* In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sciences 73:2127-2136.
  114. CC Hsu, SJ Tsai#, YL Huang, and BM Huang* 2003 Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis. FEBS Lett 543:140-143, 2003.
  115. FJ Diaz, LE Anderson, YL Wu, A Rabot, SJ Tsai, and MC Wiltbank* Regulation of progesterone and prostaglandin F2α production in the CL. Mol Cell Endocrinol 191:65-80, 2002.
  116. MH Wu, SJ Tsai, HA Pan, KY Shau, and FM Chang* Three-dimensional power Doppler imaging of ovarian stromal blood flow in women with endometriosis undergoing in vitro fertilization. Ultrasound Obstet Gynecol 21:480-485, 2003.
  117. MH Wu, HS Sun, CC Lin, KY Hsiao, PC Chuang, HA Pan, and SJ Tsai* Distinct mechanisms regulate cyclooxygenase-1 and -2 in peritoneal macrophages of women with and without endometriosis. Mol Hum Reprod 8:1103-1110, 2002.
  118. Wu MH, Chuang PC, Chen SM, and Tsai SJ* Expression of leptin in endometriotic cells is associated with endometrial stromal cell proliferation and leptin gene upregulation. Mol Hum Reprod 8:456-464, 2002.
  119. SJ Tsai, MH Wu, SM Chen, PC Chuang, and LC Wing* Fibroblast growth factor-9 is an endometrial stromal growth factor. Endocrinology 143:2715-2721, 2002.
  120. Pan HA, SJ Tsai, CW Chen, YC Lee, YM Lin, PL Kuo* 2002 Expression of DAZL protein in human corpus luteum. Mol Hum Reprod 8:540-545.
  121. YM Lin, CW Chen, HS Sun, SJ Tsai, JS Lin, PL Kuo* Presence of DAZL transcript and protein in mature human spermatozoa. Fertil Steril 77:626-629, 2002.
  122. AL Yang, SJ Tsai, MJ Jiang, CJ Jen, HI Chen* Chronic exercise increases both inducible and endothelial nitric oxide synthase gene expression in endothelial cells of rat aorta. J Biomed Sci 9:149-155, 2002.
  123. SJ Tsai*, MH Wu, CC Lin, HS Sun, and SM Chen Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells. J Clin Endocrinol Metab 86:5765-5773, 2001.
  124. YM Lin, CW Chen, HS Sun, SJ Tsai, CC Hsu, YN Teng, JS Lin, PL Kuo* Expression patterns and transcript concentrations of the autosomal DAZL gene in testes of azoospermic men. Mol Hum Reprod 7:1015-1022, 2001.
  125. PS Leung*, SJ Tsai, G Wallukat, TN Leung, and TK Lau The upregulation of angiotensin II receptors in human preeclamptic placenta. Mol Cell Endocrinol 184:95-102, 2001.
  126. BM Huang*, CC Hsu, SJ Tsai, and SF Leu Effects of Cordyceps sinensis on testosterone production in normal mouse Leydig cells. Life Sciences 69:2593-2602, 2001.
  127. SJ Tsai*, MH Wu, PC Chuang, and SM Chen Distinct regulation of gene expression by prostaglandin F2α (PGF2α) is associated with PGF2α-resistance or susceptibility in human granulosa-lutein cells. Mol Hum Reprod 7:415-423, 2001.
  128. SJ Tsai* and MC Wiltbank Differential effects of prostaglandin F2α on in vitro luteinized bovine granulosa cells. Reproduction 122:245-253, 2001.
  129. SJ Tsai, K Kot, OJ Ginther, and MC Wiltbank* Temporal gene expression in the corpus luteum after treatment with prostaglandin F2α based on serial in vivo biopsies. Reproduction 121:905-913, 2001.
  130. LE Anderson, YL Wu, SJ Tsai, MC Wiltbank* Prostaglandin F2α receptor in the corpus luteum: Recent information on the gene, messenger ribonucleic acid, and protein. Biol Reprod 64:1041-1047, 2001.
  131. K Kot, LE Anderson, SJ Tsai, MC Wiltbank and OJ Ginther* Transvaginal ultrasound-guided biopsy of the corpus luteum in cattle. Theriogenology 52:987-993, 1999.
  132. SJ Tsai, LE Anderson, JL Juengel, GD Niswender, MC Wiltbank* 1998 Regulation of prostaglandin F2α and E receptor mRNA by prostaglandin F2α in ovine corpora lutea. J. Reprod Fertil 114:69-75.
  133. SJ Tsai, MC Wiltbank* Prostaglandin F2α regulates distinct physiological changes in early and mid-cycle bovine corpora lutea. Biol Reprod 58:346-352, 1998.
  134. SJ Tsai, MC Wiltbank* Prostaglandin F2α induces expression of prostaglandin G/H synthase-2 in the corpus luteum: A positive feedback loop during luteolysis. Biol Reprod 57:1016-1022, 1997.
  135. SJ Tsai, JL Juengel, MC Wiltbank* Hormonal regulation of monocyte chemoattractant protein-1 gene expression in the corpora lutea. Endocrinology 138:4517-4520, 1997.
  136. PD Burns, SJ Tsai, MC Wiltbank, SH Hayes, GA Graf, WJ Silvia* Effect of oxytocin on concentrations of prostaglandin H synthase-2 mRNA in ovine endometrial tissue in vivo. Endocrinology 138:5637-5640, 1997.
  137. SJ Tsai, MC Wiltbank*, KJ Bodensteiner Distinct mechanisms regulate induction of messenger ribonucleic acid for prostaglandin (PG) G/H synthase-2, PGE (EP3) receptor, and PGF2α receptor in bovine preovulatory follicles. Endocrinology 137:3348-3355, 1996.
  138. SJ Tsai, MC Wiltbank* Quantification of mRNA using competitive RT-PCR with standard curve methodology. BioTechniques 21:862-866, 1996.
  139. TM Duello*, SJ Tsai, PJ Van Ess In situ demonstration and characterization of progonadotropin-releasing hormone messenger ribonucleic acid in the first trimester human placentas. Endocrinology 133:2617-2623, 1993.
  140. CC Yuan*, LC Tsai, SC Hsu, HT Ng, SJ Tsai, HM Chen, MW Hung, CK Ho, DM Ho, TJ Gill III Production and characterization of a monoclonal antibody (Cx-99) against cervical carcinoma. Br J Cancer 65:201-207, 1992.
  141. LC Tsai*, RB Tang, MW Hung, HM Chen, SJ Tsai Expression of serum IL-2, IL-2R, and CD8 levels during hyposensitization in house-dust-sensitive asthmatics. J Asthma 27:307-313, 1990.
  142. LC Tsai*, MW Hung, HM Chen, ZN Chang, SJ Tsai Measurement of specific IgE antibody in mite-sensitive asthmatic children by enzyme-linked immunosorbent assay. Chin Med J (Taipei) 44:352-357, 1989.
  143. CC Yuan, LC Tsai*, SJ Tsai, SC Hsu, DM Ho, HM Chen, MW Hung, LC Lee, HT Ng Immunohistochemical study of carcinoembryonic antigen in cervical cancer-using a monoclonal antibody Mab C27. Chin Med J (Taipei) 44:341-346, 1989.

專書章節

  1. WN Li, MH Wu, and SJ Tsai* Hypoxia & immune factors. Immunology of Endometriosis: Pathogenesis & management. P121-131. Kaori Koga (Ed) Springer Nature, 2022, September.
  2. KY Hsiao, MH Wu, SJ Tsai* Roles of Prostaglandins in Endometriosis. In Endometriosis book, Tasuku Harada (Ed), 2014
  3. SJ Tsai Endocrinology. In Human Physiology SG Fan, H Tang, H Chang and PWF Poon (Eds) Beijing Medical University and Beijing Union Medical University Press, 2000.
  4. SJ Tsai, MC Wiltbank Standard curve quantitative, competitive-RT-PCR (SC-QC-RT-PCR): A simple method to quantify absolute concentration of mRNA from limited samples. In RT-PCR Methods for Gene Cloning and Analysis. P. Siebert (Ed), Eaton Publishing, Natick, MA, 1998
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