Tel: (05)2720411 ext. Office 66500 Lab 61506

 Fax: (05)2722871

 Email: biomly@ccu.edu.tw

Ph.D. Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan

• 2025/02  Assistant Professor, Department of Biomedical Sciences, National Chung Cheng University.
• 2023/10-2025/01  Postdoctoral Fellow in Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
• 2021/02-2023/07  Postdoctoral Fellow in Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.
• 2014/01-2021/01  Postdoctoral Fellow in Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
• 2013/01-2013/12 Postdoctoral Fellow in Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
• 2012/08-2012/12 Research Fellow in Department of Pharmacy, National University of Singapore.

• Virology
• Immunology
• Gene and cell therapy
• Vaccinology

• Investigating pathogenesis of dengue virus-induced thrombocytopenia
• Studying the association between host factors and high-risk pregnancy diseases through translational medicine approaches
• Developing strategies for cancer gene and cell therapy

• 吳文鑾、楊玫琳、蕭璦莉、吳昭良。2006。干擾素誘導之表現雙股 RNA 之核酸分子。中華民國專利公開編號I347362。
• 蕭璦莉、楊玫琳、陳毓宏、吳昭良。 2015。用以製備流感疫苗之複合物、新型流感疫苗及其製備方法。中華民國專利公開編號I493038。

1. 1. Yang M.L., F.M. Chang, M.H. Wu, C.H. Chen, T.L. Cheng, L. Kang. Association studies of vasoactive genes and preeclampsia in Taiwan. Placenta (accepted, in press)
   2. Yang M.L., C.Y. Hu, Y.C. Lee, C.C. Chang, Y.C. Chen, P.R. Lee, B.H. Su, P.C. Chen, A.L. Shiau, G.S. Shieh, C.L. Wu, P. Wu. Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy. Stem Cells Translational Medicine 2024, szae039.
   3. Yang M.L., C.L. Lin, Y.C. Chen, I.A. Lu, B.H. Su, Y.H. Chen, K.T. Liu, C.L. Wu, A.L Shiau. Prothymosin α accelerates thrombocytopenia caused by dengue virus infection. iScience 2024, 27:108422.
   4. Yang M.L., Y.C. Chen, C.T. Wang, H.E. Chong, N.H. Chung, C.H. Leu, F.T. Liu, Michael M.C. Lai, P. Ling, C.L. Wu, A.L. Shiau. Upregulation of galectin-3 in influenza A virus infection promotes viral RNA synthesis through its association with viral PA protein. Journal of Biomedical Science 2023, 30:14.
   5. Yang M.L., Y.J. Huang, Y.C. Lin, Y.H. Lin, T.T. Hung, A.L. Shiau, H.C. Cheng, C.L. Wu. Multivalent dipeptidyl peptidase IV fragment-nanogold complex inhibits cancer metastasis by blocking pericellular fibronectin. Biomaterials Advances 2023, 148: 213357.
   6. S.Y. Chen, C.T. Chu, M.L. Yang, J.D. Lin, C.T. Wang, C.H. Lee, I.C. Lin, A.L. Shiau, P. Ling, C.L. Wu. Amelioration of murine colitis by attenuated Salmonella choleraesuis encoding interleukin-19. Microorganisms 2023, 11:1530.
   7. Hu C.Y., B.H. Su, Y.C. Lee, C.T. Wang, M.L. Yang, W.T. Shen, J.T. Fu, S.Y. Chen, W.Y. Huang, C.H. Ou, Y.S. Tsai, F.C. Kuo, A.L. Shiau, G.S. Shieh, C.L. Wu. Interruption of the long non-coding RNA HOTAIR signaling axis ameliorates chemotherapy-induced cachexia in bladder cancer. Journal of Biomedical Science 2022, 29:104.
   8. Lin C.Y., M.C. Shih, H.C. Chang, K.J. Lin, L.F. Chen, S.W. Huang, M.L. Yang, S.K. Ma, A.L. Shaiu, J.R. Wang, K.R. Chen, P. Ling. Influenza A virus NS1 resembles a TRAF3-interacting motif to target the RNA sensing-TRAF3-type I IFN axis and impair antiviral innate immunity. Journal of Biomedical Science 2021, 28: 66.
   9. Chen Y. C., Y.C. Chou, Y.T. Hsieh, P.Y. Kuo, M.L. Yang, H.E. Chong, C. L. Wu, A.L.Shiau, C.R. Wang. Targeting intra-pulmonary P53-dependent long non-coding RNA expression as a therapeutic intervention for systemic lupus erythematosus-associated diffuse alveolar hemorrhage. International Journal of Molecular Sciences 2021, 22: 6948.
   10. Chen Y. C., P.Y. Kuo, Y.C. Chou, H.E. Chong, Y.T. Hsieh, M.L. Yang, C. L. Wu, A.L.Shiau, C.R. Wang. Up-regulated expression of pro-apoptotic long noncoding RNA lincRNA-p21 with enhanced cell apoptosis in lupus nephritis. International Journal of Molecular Sciences 2020, 22: 301.
   11. Yang M.L., C.T. Wang, S.J. Yang, C.H. Leu, S.H. Chen, C.L. Wu, A.L. Shiau. IL-6 ameliorates acute lung injury in influenza virus infection. Scientific Reports 2017; 7: 43829.
   12. Leu G.H., M.L. Yang, N.H. Chung, Y.J. Huang, Y.C. Chen, C.C. Lin, G.S. Shieh, M.Y. Chang, J. Chao, L. Chao, C.L. Wu, A.L. Shiau. Kallistatin ameliorates influenza virus pathogenesis by inhibition of kallikrein-related peptidase 1-mediated cleavage of viral hemagglutinin. Antimicrobial Agents and Chemotherapy 2015; 59:5619-30.
   13. Lin Y.Y., J.D. Liao, M.L. Yang, C.L. Wu. Target-size embracing dimension for sensitive detection of viruses with various sizes and influenza virus strains. Biosensors and Bioelectronics 2012; 35:447-451.
   14. Yang M. L., Y. H. Chen, S. W. Wang, Y. J. Huang, C.H. Leu, N. C. Yeh, C. Y. Chu, C. C. Lin, G. S. Shieh, Y.L. Chen, J. R. Wang, C. H. Wang, C. L. Wu, A. L. Shiau. Galectin-1 binds to influenza virus and ameliorates influenza pathogenesis. Journal of Virology 2011; 85:10010-10020.